| 透骨消痛胶囊干预膝骨性关节炎软骨下骨重塑分子机制探讨 |
| |
| 引用本文： | 李民,陈文列,刘献祥,林久茂,黄云梅,黄梅雅,吴追乐,郑春松.透骨消痛胶囊干预膝骨性关节炎软骨下骨重塑分子机制探讨[J].福建中医学院学报,2009,19(6):35-39. |
| |
| 作者姓名： | 李民 陈文列 刘献祥 林久茂 黄云梅 黄梅雅 吴追乐 郑春松 |
| |
| 作者单位： | 1. 福建中医学院附属漳州市中医院,福建,漳州,363000
2. 福建中西医结合研究院,福建,福州,350108 |
| |
| 基金项目： | 国家自然科学基金，福建省科技厅重点项目，福建省卫生厅青年基金 |
| |
| 摘 要： | 目的 观察透骨消痛胶囊干预骨性关节炎软骨下骨重塑的作用及机制.方法 128只新西兰大白兔随机分4组,除正常组外均按改良Hulth法造模.正常组、模型组予生理盐水10 mL/d灌胃,对照组予壮骨关节丸水溶液10 mL/d灌胃,实验组予透骨消痛胶囊水溶液10 mL/d灌胃,术后分批分次处死取材.RT-PCR法检测软骨下骨c-fos、β-Catenin、RANKL和软骨MMP-1 mRNA的表达.结果 与正常组比较,造模后6周、9周、12周,实验组各指标表达均较高(P＜0.05).与模型组比较,造模后1周,实验组c-fos mKNA表达较低(P＜0.05);造模后6周,实验组RANKL、MMP-1 mRNA表达较低(P＜0.05);造模后9周和12周,实验组各项指标表达均较低(P＜0.05).与对照组比较,造模1周后,实验组c-fos mRNA表达较低(P＜0.05);6周时实验组RANKL、MMP-1 mRNA 表达较低(P＜0.05);9周、12周后,实验组β-Catenin、MMP-1 mRNA表达较低(P＜0.05).结论 透骨消痛胶囊可改变软骨下骨重塑的速率和模式,最终减轻软骨下骨硬化.
|
| 关 键 词： | 透骨消痛胶囊 骨性关节爽 软骨下骨 分子生物学 |
Approach on Molecular Mechanism of Subchondral Bone Remodeling in Knee Osteoarthritis Treated with Touguxiaotong Granula |
| |
| LI Min,CHEN Wen-lie,LIU Xian-xiang,et al.Approach on Molecular Mechanism of Subchondral Bone Remodeling in Knee Osteoarthritis Treated with Touguxiaotong Granula[J].Journal of Fujian College of Traditional Chinese Medicine,2009,19(6):35-39. |
| |
| Authors: | LI Min CHEN Wen-lie LIU Xian-xiang |
| |
| Institution: | LI Min1,CHEN Wen-lie2,LIU Xian-xiang2,et al(1.Zhangzhou Hospital of Traditional Chinese Medicine,Zhangzhou,Fujian 363000,China,2.Fujian Academy of Integrative Medicine,Fuzhou,Fujian 350108,China) |
| |
| Abstract: | Objective To observe the effect of Tougu Xiaotong granula(TGXT) on subchondral bone remodeling and investigate the mechanism.Methods 128 New Zealand rabbits were divided into 4 groups,i.e,normal group,model group,control group and experimental group,32 rabbits per-group.Except for the normal group,the other three groups were operated on according to the improved method of Hulth.The normal group and the model group were perfused with normal saline 10 ml / d,at the same time the control group and the experime... |
| |
| Keywords: | Tougu Xiaotong granula osteoarthritis subchondral bone molecular biology |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
