首页 | 本学科首页   官方微博 | 高级检索  
检索        

Effects of Liandou Qingmai Recipe(连豆清脉方) on Endothelin-1,Nitric Oxide,Interleukin-6 and Interleukin-10 Levels in Patients with Coronary Heart Disease
引用本文:朱红俊,陆曙,苏伟,龚少愚,张志斌,李萍,魏慧渊,杨庆有,唐虹,夏成霞,朱明.Effects of Liandou Qingmai Recipe(连豆清脉方) on Endothelin-1,Nitric Oxide,Interleukin-6 and Interleukin-10 Levels in Patients with Coronary Heart Disease[J].中医杂志(英文版),2011(3):173-177.
作者姓名:朱红俊  陆曙  苏伟  龚少愚  张志斌  李萍  魏慧渊  杨庆有  唐虹  夏成霞  朱明
作者单位:Heart Internal Medicine Department;Wuxi Hospital Affiliated to Nanjing University of Traditional Chinese Medicine;Nanjing University of Traditional Chinese Medicine;Wuxi City Institute of Traditional Chinese Medicine;
基金项目:supported by Bureau of Traditional Chinese Medicine of Jiangsu Province (No. HZ07097)
摘    要:Objective:To observe effects of Liandou Qingmai Recipe(连豆清脉方) on endothelin-1(ET-1),nitric oxide(NO),interleukin-6(IL-6) and IL-10 levels in patients with coronary heart disease.Methods:Total 101 cases with coronary heart disease were randomly divided into a treatment group(n=45) treated by Liandou Qingmai Recipe and a standard treatment group(control group,n=56),with a normal group of 16 health persons set up.Changes of ET-1,NO,IL-6 and IL-10 levels were measured before treatment and after treatment for two weeks.And the data were analyzed by SPSS 16.0 statistic software.Results:Before treatment,the levels of ET-1,IL-6 and IL-10 levels were significantly higher and NO was significantly lower in the patients with coronary heart disease than those in the normal group(90.7±12.7 ng/L vs 41.8±13.5 ng/L,9.17±0.18 ng/L vs 1.10±0.08 ng/L,1.94±0.26 ng/L vs 1.09±0.06 ng/L,and 92.2±17.7 μmol/L vs 124.5±27.2 μmol/L;all P<0.05),with no significant differences in the levels of ET-1,NO,IL-6 and IL-10 between the treatment group and the control group(P>0.05);After treatment,ET-1 and IL-6 significantly decreased in the treatment group and the control group,and NO increased in the treatment group;And IL-6 level was significantly lower and NO level was higher in the treatment group than those in the control group(4.48±1.22 ng/L vs 5.13±1.85 ng/L,117.4±22.3 μmol/L vs 92.4±17.1 μmol/L;both P<0.05);There was a positive correlation between IL-6 and IL-10,and a negative correlation between NO and IL-10(r=0.142,r=-0.152;both P<0.05).Conclusion:Liandou Qingmai Recipe can decline IL-6,IL-10 and ET-1 levels,and raise NO level in patients with coronary heart disease on the basis of standard treatment,so as to inhibit endothelial inflammatory response,improve vascular endothelial function,with stronger anti-AS action;And vascular endothelial lesion is related with inflammatory response.

关 键 词:coronary  heart  disease  Liandou  Qingmai  Recipe(连豆清脉方)  endothelin-1  interleukin-6  interleukin-10  nitric  oxide

Effects of Liandou Qingmai Recipe(连豆清脉方) on Endothelin-1,Nitric Oxide,Interleukin-6 and Interleukin-10 Levels in Patients with Coronary Heart Disease
ZHU Hong-jun,LU Shu,SU Wei,GONG Shao-yu,ZHANG Zhi-bin,LI Ping,WEI Hui-yuan,YANG Qing-you,TANG Hong,XIA Cheng-xia, ZHU Ming .Heart Internal Medicine.Effects of Liandou Qingmai Recipe(连豆清脉方) on Endothelin-1,Nitric Oxide,Interleukin-6 and Interleukin-10 Levels in Patients with Coronary Heart Disease[J].Journal of Traditional Chinese Medicine,2011(3):173-177.
Authors:ZHU Hong-jun    LU Shu  SU Wei  GONG Shao-yu  ZHANG Zhi-bin  LI Ping  WEI Hui-yuan  YANG Qing-you  TANG Hong  XIA Cheng-xia  ZHU Ming Heart Internal Medicine
Institution:ZHU Hong-jun1,2,LU Shu1,SU Wei1,GONG Shao-yu1,ZHANG Zhi-bin3,LI Ping3,WEI Hui-yuan1,YANG Qing-you1,TANG Hong1,XIA Cheng-xia1,and ZHU Ming1 1.Heart Internal Medicine Department,Wuxi Hospital Affiliated to Nanjing University of Traditional Chinese Medicine,Jiangsu 214001,China,2.Nanjing University of Traditional Chinese Medicine,Nanjing,3.Wuxi City Institute of Traditional Chinese Medicine,Wuxi,China.
Abstract:
Keywords:
本文献已被 CNKI 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号