| 脑溢安对出血性中风大鼠脑内磷酸化蛋白激酶表达的影响 |
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| 引用本文： | 聂亚雄,黎杏群,袁梦石,张花先,张化彪,唐涛.脑溢安对出血性中风大鼠脑内磷酸化蛋白激酶表达的影响[J].湖南中医药大学学报,2001,21(2):20-22. |
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| 作者姓名： | 聂亚雄 黎杏群 袁梦石 张花先 张化彪 唐涛 |
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| 作者单位： | 1. 中南大学湘雅医院中西医结合研究所,
2. 湖南中医学院第一附属医院, |
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| 基金项目： | 国家科技部新药开发项目! (96 -90 1-0 5 -2 2 5 ) |
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| 摘 要： | 探讨脑溢安对出血性中风大鼠脑内磷酸化蛋白激酶（P－C－Jun）表达的影响和治疗机理。根据 Roserberg法复制大鼠脑出血模型，采用免疫组织化学方法观察脑出血后梨状皮质内P－C－Jun的表达变化，并用组织病理学方法分析脑皮质内神经元的损伤状况。结果：脑溢安治疗组较模型组脑内P－C－Jun蛋白表达弱，神经元受损状况轻。结论：脑溢安下调脑内P－C－Jun蛋白表达，从而干预了丝裂原活化的蛋白激酶（MAPK）信号转导通路。
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| 关 键 词： | 脑溢安 脑出血 中风 磷酸化蛋白激酶 信号转导 平肝熄风 羚羊角 大黄 |
| 文章编号： | 1000-5633(2001)02-0020-03 |
| 修稿时间： | 2000年12月25 |
Effect of Nao Yi An on the Expression of P-C-Jun in the Brain of Experimental Intracerebral Hemorrhagic Rat |
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| Nie Yaxiong,Li Xingqun,Yuan Mongshi,et al.Effect of Nao Yi An on the Expression of P-C-Jun in the Brain of Experimental Intracerebral Hemorrhagic Rat[J].Journal of Traditional Chinese Medicine University of Hunan,2001,21(2):20-22. |
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| Authors: | Nie Yaxiong Li Xingqun Yuan Mongshi |
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| Abstract: | To investigate the effect of traditional Chinese medicine Nao Yi An (NYA) on the expression of P-C-Jun in the brain of experimental intracerebral hemorrhagic rat.The rats were randomly divided into the normal control group,the model control group and NYA treatment group.By injecting collagenase type Ⅶ stereotaxically into the right globas pallidus,rat models with haemorrhagic stroke were made.We investigated the changes of the expression of P-CJun in the piriform cortex of the rats.Results：The expression of P-C-Jun in NYA group was weaker than that in the model control group(P＜0.05).Conclusion：NYA interferes in the expression of P-C-Jun in the brain of rat models with haemorrhagic stroke，and affects the MAPK signal transduction. |
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| Keywords: | Nao Yi An haemorrhagic stroke Phospho C Jun MAPK JNK calming liver wind Radix et Rhizoma Rhei Corun Saigae Tataricae |
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