| 大脑中动脉线栓法脑缺血模型制作的改进及经验探讨 |
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| 引用本文： | 卢 英,蔡光先,谭 琥,邓叔华,易 健,刘柏炎.大脑中动脉线栓法脑缺血模型制作的改进及经验探讨[J].湖南中医药大学学报,2014(1):6-9. |
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| 作者姓名： | 卢 英 蔡光先 谭 琥 邓叔华 易 健 刘柏炎 |
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| 作者单位： | [1]湖南中医药大学2011级硕士研究生班,湖南长沙410208 [2]湖南中医药大学第一附属医院省部共建教育部重点实验室,湖南长沙410007 [3]益阳医学高等专科学校,湖南益阳413000 |
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| 基金项目： | 国家自然科学基金（81072939,81273989）;湖南省高校创新平台开放基金（09K056,10K048,12K089）. |
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| 摘 要： | 目前局灶性脑缺血动物模型最常用的方法是大脑中动脉线栓法（MCAO）,但该方法仍存在技术要求高、模型差异性大、动物死亡率高等缺陷.因此,如何建立稳定、可靠、重复性高的MCAO动物模型成为我们亟需解决的问题.从实验动物、麻醉药物、栓线的选择,手术流程、术后护理等多个方面进行探讨,以期提高MCAO脑缺血动物模型的成功率.
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| 关 键 词： | 大脑中动脉线栓法 脑缺血 模型大鼠 |
Experience and improvement of preparation of the cerebral ischemia model by string-fastenings method for middle cerebral artery occlusion |
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| Lu Ying,CAI Guangxian,TAN Hu,DENG Shuhua,YI Jian,LIU Boyan.Experience and improvement of preparation of the cerebral ischemia model by string-fastenings method for middle cerebral artery occlusion[J].Journal of Traditional Chinese Medicine University of Hunan,2014(1):6-9. |
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| Authors: | Lu Ying CAI Guangxian TAN Hu DENG Shuhua YI Jian LIU Boyan |
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| Institution: | 1.2011 Class of master degree candidate, Hunan University of CM,Changsha, Hunan 410208, China; 2.Key Laboratory of Ministry of Education, First Affiliated Hospital, Hunan University of CM,Changsha, Hunan 410007, China; 3.Yiyang Medical College, Yiyang, Hunan 413000, China;) |
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| Abstract: | The most common method for establishment of animal model of focal cerebral ischemia is the string-fastenings method for middle cerebral artery occlusion,but there are several defects for the method such as demanding technics,marked differences in model animals,high mortality.Therefore,establishing a stable,reliable,and reproducible animal model of focal cerebral ischemia has become an urgent problem.The choice of animal,anesthetic drugs and bolt lines,surgical procedures and postoperative care are discussed in this article in order to improve the success rate of focal cerebral ischemia model by the suture of middle cerebral artery. |
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| Keywords: | the string-fastenings method for middle cerebral artery occlusion cerebral ischemia model rat |
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