| 咳喘宁对哮喘豚鼠EOS的调节作用 |
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| 引用本文： | 董晓斐,罗银河,王孟清,陈锡军,朱晔.咳喘宁对哮喘豚鼠EOS的调节作用[J].湖南中医药大学学报,2008,28(5). |
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| 作者姓名： | 董晓斐 罗银河 王孟清 陈锡军 朱晔 |
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| 作者单位： | 湖南中医药大学第一附属医院,湖南长沙,410007 |
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| 摘 要： | 目的 现察咳喘宁对哮喘豚鼠嗜酸性粒细胞(EOS)的调节作用,阐明其防治哮喘的作用机制.方法 用卵清蛋白复制豚鼠哮喘模型,以地塞米松为阳性对照药,现察咳喘宁干预后血中和肺泡灌洗液中EOS的改变情况.结果 咳喘宁能有效降低哮喘琢鼠血和肺泡灌洗液中EOS的数量,与模型组相比羔异有统计学意义(P<0.05).地塞米松降低血中EOS的效果优于咳喘宁.但差异无统计学意义(P>0.05).结论 咳喘宁能降低哮喘豚鼠血中和肺泡灌洗液中EOS水平.
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| 关 键 词： | 咳喘宁 哮喘 地塞米松 嗜酸性粒细胞 豚鼠 麻黄 杏仁 |
Effect of Kechuanning on adjusting EOS in asthma guinea pigs |
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| DONG Xiao-fei,LUO Yin-he,WANG Meng-Qing,CHEN Xi-jun,ZHU Ye.Effect of Kechuanning on adjusting EOS in asthma guinea pigs[J].Journal of Traditional Chinese Medicine University of Hunan,2008,28(5). |
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| Authors: | DONG Xiao-fei LUO Yin-he WANG Meng-Qing CHEN Xi-jun ZHU Ye |
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| Institution: | DONG Xiao-fei,LUO Yin-he,WANG Meng-Qing,CHEN Xi-jun,ZHU Ye(First Affiliated Hospital,TCM University of Hunan,Changsha,Hunan 410007,China) |
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| Abstract: | Objective To observe the effect of Kechuanning(KCN) on regulating the level of EOS in asthma guinea pigs and study the mechanism of prevention and treatment.Methods The pig models were induced by aerosolized ovalbvmin,and compared with dexamethasone,the effects of KCN were measured on changes of EOS in serum and in bronchoalveolar lavage(BALF).Results The contents of EOS in serum and BALF were marked decreased compared with MG(P<0.05),and dexamethasone was more effective to decrease the serum EOS than KCN w... |
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| Keywords: | Kechuanning asthma dexamethasone EOS guinea pigs Ephedra sinica almond |
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