枸杞多糖抗小鼠实验性肝癌的作用机制

目的探讨枸杞多糖（LBP）抗小鼠实验性肝癌的作用机制。方法采用H22实验性肝癌小鼠模型，LBP连续灌胃治疗14d。绘制肿瘤生长体积曲线图、计算肿瘤生长抑制率。同时对各组胸腺及肿瘤组织进行病理检查。结果LBP可踢显减小肿瘤体积。肿瘤生长抑制率在高剂量组达到41．12％，与模型组闻比较差异具统计学意义（P〈0．05）。在肝癌模型组胸腺体质量较对照组明显减轻，皮质变薄，LBP用药后肝癌小鼠胸腺体质量及胸腺指数有所恢复，并在高剂量组与模型组间比较差异具统计学意义（P〈0．05）。肿瘤组织病理检查结果，发现LBP高、低剂量组肿瘤细胞核分裂计数明显下降，与模型组比较差异具统计学意义（P〈0．05）；肿瘤间质纤维组织增生及淋巴细胞浸润在LBP用药后亦明显增加，高剂量组与模型组比较差异具统计学意义（P〈0．05）；肿瘤细胞增殖密度和坏死程度在各组之间比较差异无统计学意义。结论LBP对实验性肝癌小鼠肿瘤细胞的生长具有一定的抑制作用，其具体作用机制与增强机体整体及局部的免疫功能有关．具体的作用环节有待进一步深入探讨。

Mechanism of Lycium barbarum polysaccharide on anti-tumor effects for experimental liver cancer in mice

Objective To investigate the mechanism and the effects of Lycium barbarum polysaccharide(LBP) on anti-tumor in experimental liver cancer in mice.Method H22 bear-ing mice models were established fed with LBP in 14 days.The therapeutic effects was determined with inhibition rate of tumor growth and thymus index,and the thymus and tu-mor tissues were examinated with conventional pathological method.Results LBP could inhibit tumor growth and the inhibition ratio in high dose group was 41.12%,compared with model...