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加减苍附导痰汤调控痰湿阻滞型多囊卵巢综合征患者子宫内膜容受性研究
引用本文:王慧颖,林 喧.加减苍附导痰汤调控痰湿阻滞型多囊卵巢综合征患者子宫内膜容受性研究[J].湖南中医药大学学报,2014(6):31-34.
作者姓名:王慧颖  林 喧
作者单位:广州中医药大学第一附属医院妇科,广东广州510405
基金项目:广东省科技厅资助项目(2010B030700042)
摘    要:目的观察加减苍附导痰汤对痰湿阻滞型多囊卵巢综合征(PCOS)患者子宫内膜整合素αvβ3、葡萄糖转运体4(GLUT4)表达的影响以探讨该方对子宫内膜容受性的影响。方法收集符合证型患者90例,随机分为加减苍附导痰汤组(中药组)、克罗米芬组(西药组)、加减苍附导痰汤+克罗米芬组(中西药组)各30例。对照组为输卵管性不孕患者30例。连续治疗3个月经周期,观察各组治疗前后排卵率、妊娠率和免疫组化法检测整合素αvβ3、GLUT4表达。结果治疗后中药组的排卵率低于其他3组(P〈0.05),中西药组与西药组排卵率差异无统计学意义(P〉0.05),且均低于对照组(P〈0.05);中药组、中西药组的妊娠率均高于西药组(P〈0.05);治疗前PCOS各组αvβ3、GLUT4表达均显著低于对照组(P〈0.01);中药组、中西药组治疗后整合素αvβ3、GLUT4表达较治疗前升高(P〈0.05);西药组治疗后整合素αvβ3的表达较治疗前下降(P〈0.05),GLUT4表达治疗前后差异无统计学意义(P〉0.05)。结论加减苍附导痰汤能一定程度上拮抗克罗米芬促排后降低子宫内膜容受性的作用;能有效增加痰湿阻滞型PCOS患者子宫内膜整合素αvβ3、GLUT4,可提高子宫内膜容受性,从而提高受精卵着床率。

关 键 词:多囊卵巢综合征  痰湿阻滞证  加减苍附导痰汤  整合素αvβ3  葡萄糖转运体4

Research on Jiajian Cangfu Daotan Decoction in Treating Endometrial Receptivity in Dampness-phlegm Obstructing Type Patients with Polycystic Ovary Syndrome
WANG Huiyin,LIN Xuan.Research on Jiajian Cangfu Daotan Decoction in Treating Endometrial Receptivity in Dampness-phlegm Obstructing Type Patients with Polycystic Ovary Syndrome[J].Journal of Traditional Chinese Medicine University of Hunan,2014(6):31-34.
Authors:WANG Huiyin  LIN Xuan
Institution:(Department of the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China)
Abstract:Objective To study the effect of Jiajian Cangfu Daotan Decoction on endometrial receptivity in the dampness-phlegm obstructing type patients with polycystic ovary syndrome(PCOS).Methods 90 patients with the dampness-phlegm obstructing type of polycystic ovary syndrome(PCOS) patients were collected who aged between 22-40 years old. All patients were randomly divided into the traditional Chinese medicine group(30 cases), the clomiphene group(30 cases) and Chinese medicine combined clomiphene group(30 cases). The control group of 30 patients with tubal infertility. For a course of treatment, observation statistics the ovulation rate,pregnancy rate, TCM syndrome integral, menstrual score, expression of integrin αvβ3, GLUT4.Results After treatment, the ovulation rate of traditional Chinese medicine group was lower than other three groups, with significant difference(P〈0.05). The Chinese medicine combined clomiphene group:after treatment, integrin αvβ3, GLUT4 s expression had enhanced compared with non-treatment, there were significant difference, the same as Chinese medicine group. Clomiphene group: the expression of integrin αvβ3 decreased than before treatment. The GLUT4 express did not show statistically significant before and after treatment. Conclusion Jiajian Cangfu Daotan Decoction can effectively increase polycystic ovary syndrome with stagnation and blockade of phlegm-damp patients, integrinαvβ3, GLUT4 expression. It can improve the receptivity of the fertilized egg implantation rate.
Keywords:polycystic ovary syndrome  dampness-phlegm obstructing  Jiajian Cangfu Daotan Decoction  GLUT4  αvβ3
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