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| 雄性“肾阳虚”亚健康大鼠模型的研究 | |
| 引用本文： | 李天禹,何清湖,卢芳国,刘朝圣,万胜.雄性“肾阳虚”亚健康大鼠模型的研究[J].湖南中医药大学学报,2011,31(1):22-24. |
| 作者姓名： | 李天禹 何清湖 卢芳国 刘朝圣 万胜 |
| 作者单位： | 1. 遵义医学院附属医院中医科,贵州,遵义,410208 2. 湖南中医药大学,湖南,长沙,410208 3. 湖南中医药大学2008级博士研究生班,湖南,长沙,410208 |
| 基金项目： | 湖南省教育厅科学研究青年项目(08B057); 湖南省研究生科研创新基金项目(CX2009B173) |
| 摘 要： | 目的研究雄性"肾阳虚"亚健康大鼠模型,为调理男性肾阳虚亚健康找寻科学配方。方法控制用药剂量及灌胃时间,用维生素B4建立雄性"肾阳虚"亚健康大鼠模型,检测腺垂体-睾丸轴激素、氧化损伤因子及抗氧化损伤因子、睾丸组织微细结构作为判断亚健康组织学依据。结果与正常大鼠相比较,模型大鼠血清FSH、LH、T均降低,均有统计学意义;模型大鼠血清SOD下降,差异有统计学意义(P<0.05);MDA增加,差异有统计学意义(P<0.01);模型大鼠睾丸组织曲细精管规则,管腔变大,精子尾部有融合现象,生精细胞层次减少,排列较紊乱,出现空泡现象。结论运用维生素B4建立的雄性"肾阳虚"亚健康大鼠模型成功。 |
| 关 键 词： | 肾阳虚 亚健康 维生素B4 大鼠 |
Study on sub-health model of male Kidney-yang deficiency in rats |
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| LI Tian-yu,HE Qing-hu,LU Fang-guo,LIU Chao-seng,WAN Sheng.Study on sub-health model of male Kidney-yang deficiency in rats[J].Journal of Traditional Chinese Medicine University of Hunan,2011,31(1):22-24. | |
| Authors: | LI Tian-yu HE Qing-hu LU Fang-guo LIU Chao-seng WAN Sheng |
| Institution: | LI Tian-yu,HE Qing-hu,LU Fang-guo,LIU Chao-seng,WAN Sheng(Affiliated Hospital,Zunyi Medical College,Zunyi,Guizhou 563000,China) |
| Abstract: | Objective To explore the sub-health model of male Kidney-yang deficiency in rats and look for a method for regulation of male Kidney-yang deficiency in human.Method Vitamin B4 was used to set up the sub-health rats model of male Kidney-yang deficiency,the level of anterior pituitary-testiculus axle hormone,the content of oxidative damage factors and anti-oxidative damage factors,the fine structure of testicle tissue were detected to measure histological baseness in sub-health condition.Result Compared with ... |
| Keywords: | Kidney-yang deficiency sub-health vitamin B4 rats |
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