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九香止泻片素片成型工艺研究
引用本文:罗堃,滕久祥,彭芝配,严建业,颜红,何群.九香止泻片素片成型工艺研究[J].湖南中医药大学学报,2009,29(2):40-42.
作者姓名:罗堃  滕久祥  彭芝配  严建业  颜红  何群
作者单位:湖南中医药大学,湖南,长沙,410208
基金项目:湖南省教育厅重点科研项目 
摘    要:目的研究九香止泻片素片最佳成型工艺条件,为该制荆包肠溶哀奠定基础。方法通过单因素重复试验,考察了黏合剂的种类、稀释剂和崩解剂的配比、崩解剂的加入方法及压片机压力对本制剂成型性能的影响。结果最优工艺条件:干浸膏粉:乳糖:微晶纤维素(内、外各加4%)的配比为100:18:8,5%PVPp5%乙醇液为黏合剂,0.5%硬脂酸镁为润滑剂,压片机压力为9.5kg。结论按此工艺参数制粒、压片,素片成型性能最佳,质量符合《中国药典》规定和包肠溶衣的要求。

关 键 词:九香止泻片  素片  成型工艺

Study on formation process of Jiuxiang Zhixie enteric-coated compressed tablets
LUO Kun,TENG Jiu-xiang,PENG Zhi-pei,YAN Jian-ye,YAN Hong,HE Qun.Study on formation process of Jiuxiang Zhixie enteric-coated compressed tablets[J].Journal of Traditional Chinese Medicine University of Hunan,2009,29(2):40-42.
Authors:LUO Kun  TENG Jiu-xiang  PENG Zhi-pei  YAN Jian-ye  YAN Hong  HE Qun
Institution:TCM University of Hunan;Changsha;Hunan 410208;China
Abstract:Objective To research the optimal formation process of Jiuxiang Zhixie enteric-coated compressed tablets.Methods through the repeated experiment with signal factor,the va-rieties of adhesives,the proportion of diluents and disintegrants,the adding methods of disinte-grants,and the pressure of the tablet press were investigated.Results The best optimal process conditions were 5% PVPK30 95%EtOH,18%lactose,8%MCC,0.5% magnesium lubricant and 9.5 kg pressure of the tablet press.Conclusion The conditions are the ...
Keywords:Jiuxiang Zhixie enteric-coated tablets  compressed-tablets  formation process  
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