大黄不同粒径粉体在家兔体内药代动力学的比较研究

目的对大黄细粉与超微粉体在兔体内的药代动力学进行对比研究。方法采用反相高效液相色谱法洲定血浆样品中大黄素、大黄酚和大黄酸的含量，用DAS2．1．1药代动力学分析软件进行数据统计分析。结果大黄素、大黄酚和大黄酸在兔体内呈二室模型，相应的t1/2α大黄细粉组分别为：0．481、1．757、1．401，大黄超微粉组分别为4．693、0．175、0．165。以细粉为参比，由AUC计算大黄超微粉的相对生物利用度为大黄素：112．57％；大黄酸113．32％；大黄酚：176．14％。结论超微粉碎技术可促进大黄有效成分的吸收，提高其生物利用度。

Comparison of pharmacokinetics in different particle diameters of Rhubarb powder in rabbits

Objective To study the comparison of pharmacokinetic characteristics of different particle diameters in Rhubarb powder in rabbits. Methods The concentration of plasma Trioxymethylanthraquinone, chrysophanol and rhein in rabbits were determined with RPHPLC method. The pharmacokinetic parameters were calculated by DAS ver2.1.1 pharmacokinetic analysis software. Results Trioxymethylanthraquinone, chrysophanol and rhein in rabbits were in two-compartment model, the corresponding t1/2α of Rhubarb powder group were 0.481, 1.757 and 1.401, the rhubarb ultra-fine powder group 4.693, 0.175 and 0.165. In reference of Rhubarb powder, the relative bioavailability were Trioxymethylanthraquinone 112.57%; Chrysophanol 113.32% and Rhein 176.14%. Conclusion Rhubarb ultra-fine powder can promote the absorption of active ingredients in Rhubarb and increase bioavailability of rhubarb powder.