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益心泰对慢性心力衰竭大鼠心肌重构和心功能的影响
引用本文:吴华堂,;吴刚强,;申思,;毛湘屏,;刘文频,;范红辉.益心泰对慢性心力衰竭大鼠心肌重构和心功能的影响[J].湖南中医药大学学报,2014(7):23-26.
作者姓名:吴华堂  ;吴刚强  ;申思  ;毛湘屏  ;刘文频  ;范红辉
作者单位:[1]湖南中医药大学第一附属医院老年病科,湖南长沙410007; [2]湖南中医药大学,湖南长沙410007; [3]湖南中医药大学第二附属医院,湖南长沙410007
基金项目:湖南省科学技术厅科技计划重点项目(2012FJ6051).
摘    要:目的探讨益气活血利水方益心泰对慢性心力衰竭大鼠心肌重构和心功能的影响。方法采用冠状动脉结扎法建立慢性心力衰竭(CHF)大鼠模型,将造模成功的SD雄性大鼠随机分为模型组、益心泰高10.4g/(kg·d)、中5.2g/(kg·d)、低2.6g/(kg·d)剂量组和科索亚组5.21g/(kg·d),另设正常对照组。模型组灌服同等体积的生理盐水,每天上午灌胃1次,连续用药8周。正常对照组不做任何处理。8周后检测心衰大鼠心脏超声指标、心肌重构指标。同时采用H—E染色观察心肌形态结构变化。结果与模型组比较,益心泰低、中、高剂量组和科索亚组LVIDs、LVIDd均显著降低,LVEF、LVFs显著升高(P〈0.05)。与模型组比较,益心泰低、中、高剂量组和科索亚组左心室质量指数、心脏指数均显著降低(P〈0.05)。光镜结果显示.益心泰高剂量组及科索亚组心肌损害程度较模型组明显减轻。结论益心泰可改善心衰大鼠的心肌重构和心功能,延缓心衰的进展。

关 键 词:益心泰  慢性心力衰竭  心肌重构  心功能(

Effect of Yixintai on Myocardial Remodeling and Heart Function in Rats with Chronic Heart Failure
Institution:WU Huatang, WU Gangqiang, SHEN Si, MAO Xiangpin, LIU Wenpin, FAN Honghui(1. Department of Gerontology, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China; 2. Hunan University of Chinese Medicine, Changsha, Hunan 410007, China; 3. The Second Affiliated Hospital of HUCM, Changsha, Hunan 410007, China)
Abstract:Objective To explore the effect of Yixintai on myocardial remodeling and heart function in rats with chronic heart failure. Methods A rat model of chronic heart failure was induced by coronary artery ligationin. Then the model rats were divided equally into five groups: model group,high-dose 10.4 g/(kg.d), middle-dose 5.2 g/(kg.d), low-dose 2.6 g/(kg.d) of Yixintai groups and Cozaar group. The normal control was also designed. The model group was received an equal volume of saline by gavage. The medication was given once daily in each treated group for 8 weeks, the normal control group received no medication. Echocardiographic indices and myocardial remodeling index was measured by echocardiography after 8 weeks of medication. Mealwhile we adopted H-E and Massion staining to observe the morphology changes of left ventricular myocardium. Results Compared with the model group, the LVIDs and LVIDd of high-dose, middle-dose, low-dose of Yixintai groups and Cozaar group was significantly decreased, but the LVEF and LVFS was significantly higher (P〈0.05). Compared with the model group, the left ventricular mass index and heart index of high-dose, middle-dose, low-dose of Yixintai groups and Cozaar group was significantly decreased (P〈0.05). As the light microscopy showed, compared with the model group, the degree of myocardial injury of high-dose Yixintai group and Cozaar group were significantly reduced. Conclusion Yixintai can improve myocardial remodeling in rats with heart failure and delay the progress of heart failure.
Keywords:Yixintai  chronic heart failure  cardiac remodeling  heart function
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