47例甲状腺癌中FasL检测的病理学意义

目的：探讨甲状腺癌FasL的表达及其意义。方法：采用免疫组化S—P法检测12例正常甲状腺组织，27例甲状腺乳头状癌和20例甲状腺髓样癌中FasL的表达，并分析FasL表达与甲状腺癌发生发展的关系。结果：甲状腺乳头状癌中均可见强弱不等的FasL表达，B组中FasL呈高表达的阳性率为81．8％，A组中则为31．2％，二间有显差异p＜0．05，在甲状腺乳头状癌中有明显间质浸润以及缺少淋巴细胞反应和肿瘤周边邻近正常组织区域癌细胞FasL表达均较强。95％的甲状腺髓样癌FasL呈高表达。结论：结果提示在甲状腺乳头状癌中FasL的高表达与肿瘤侵袭性有关，FasL表达愈强则预示其预后不良。肿瘤细胞高表达FasL可能使瘤细胞具有逃避机体免疫监视的作用。在甲状腺髓样癌中FasL的表达与甲状腺被膜浸润转移无关。

Pathological significance of investigating FasL in 47 cases of thyroid adenocarcinoma

Objective:To investigate the expression of FasL and its significance in thyroid adenocarcinomas. Methods: Immunohis-tochemical staining(S- P method) was used to detect expression of FasL in formalin - fixed and paraffin - embeded tissues from 27 cases of thyroid papillary adenocarcinomas(TPA) ,20 medullary carcinomas(MC)and 12 normal thyroid tissues. The relationship between the thyroid adenocarcinomas and the positive rates of FasL expression was analyzed. Results: FasL had various degrees of expression in TPA.The positive rate of high FasL expression was 81. 8% in group B,31. 2% in group A, with a significant difference of P<0. 05. In some specimens, FasL immunoreactivity was stronger at the peripheral edge of the carcinoma, which was in close contact with adjacent normal tissues. The positive rate of strong FasL expression in MC were 95% . Gonclusion :Our results suggest that high levels of FasL expression in TPA are related to tumor aggressiveness; also thyroid carcinoma cells ascape immune surveillance by the expression of FasL; these findings suggest that the expression of FasL in TPA may contribute to further metastases in the surrounding tissues. FasL expression in MC is not associated with infiltration of the thyroid capsule or recurrence after surgery and metastases.