| 异喹啉拉氏物烷基化反应的研究 |
| |
| 引用本文： | 余瑜,严桑和.异喹啉拉氏物烷基化反应的研究[J].重庆医科大学学报,1992,17(3):172-175. |
| |
| 作者姓名： | 余瑜 严桑和 |
| |
| 作者单位： | 重庆医科大学药物化学及生物材料研究室
(余瑜)，重庆医科大学药物化学及生物材料研究室(严桑和) |
| |
| 摘 要： |
|
| 关 键 词： | 烷基化 异喹啉拉氏物 |
STUDIES ON C_1 ALKYLATION OF REISSERT COMPOUND OF ISOQUINOL1NE |
| |
| Yu YuResearch Laboratory of Pharmaccutieal Chemistry and Biomalerials.STUDIES ON C_1 ALKYLATION OF REISSERT COMPOUND OF ISOQUINOL1NE[J].Journal of Chongqing Medical University,1992,17(3):172-175. |
| |
| Authors: | Yu YuResearch Laboratory of Pharmaccutieal Chemistry and Biomalerials |
| |
| Institution: | Yu YuResearch Laboratory of Pharmaccutieal Chemistry and Biomalerials |
| |
| Abstract: | Reissert compound of isoquinoline can be alkylated by active alkylating agent, alkyl iodide or benzyl chloride according to Barrie's method.A new compound, 1-cyclohexyl Reissert compound, was prepared by using cyclohexyl iodide as alkylating agent.If cyclohexyl bromide was used as alkylating agent in the presence of sodium hydride, the product, instead of IIIc, was 1-cyanoisoquinoline (IV) with 75% yield.It may provide a new method of preparation of IV, but the necessity of the cyclohexyl bromide and the mechanism of the reaction remain for further investition |
| |
| Keywords: | 1-alkyl Reissert compound of isoquinoline 1-cyanoisoquinoline: 1-cyclohexyl Reissert compound of isoquinoine alkvlation |
| 本文献已被 CNKI 维普 等数据库收录！ |
