| 小型猪用生物拉链的生物相容性评价 |
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| 引用本文： | 余琛琳,刘志学,马雷,蔡丽萍,徐晨,崔淑芳.小型猪用生物拉链的生物相容性评价[J].重庆医科大学学报,2011,36(9). |
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| 作者姓名： | 余琛琳 刘志学 马雷 蔡丽萍 徐晨 崔淑芳 |
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| 作者单位： | 第二军医大学训练部实验动物中心,上海,200433 |
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| 摘 要： | 目的:研究设计小型猪腹壁拉链动物模型用生物拉链,并检测、评价其生物相容性.方法:结合小型猪体型和生活习性特点、以及动物外科手术实验要求,设计生物拉链外形,并依据国家标准(GB/T 16886.10-2005/ISO 10993-10:2002),采用皮肤刺激性试验和皮肤致敏试验测定其生物相容性.结果:生物拉链具备操作简便、节省手术操作时间、减少创口感染等诸多优点,并成功获得国家知识产权专利(专利号:200920207646.1);皮肤刺激性试验未出现皮肤刺激反应;皮肤致敏试验未出现皮肤致敏反应.结论:生物拉链设计合理,具有良好的生物相容性,为小型猪腹壁拉链模型动物在教学、科研和临床中的推广应用奠定了良好的基础.
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| 关 键 词： | 生物拉链 皮肤刺激 皮肤致敏 生物相容性 |
Evaluation for biocompatibility of the biological zipper for the miniature pig |
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| YU Chen-lin,LIU Zhi-xue,MA Lei,CAI Li-ping,XU Chen,CUI Shu-fang.Evaluation for biocompatibility of the biological zipper for the miniature pig[J].Journal of Chongqing Medical University,2011,36(9). |
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| Authors: | YU Chen-lin LIU Zhi-xue MA Lei CAI Li-ping XU Chen CUI Shu-fang |
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| Institution: | YU Chen-lin,LIU Zhi-xue,MA Lei,CAI Li-ping,XU Chen,CUI Shu-fang(Laboratory Animal Center,Training Department,the Second Military Medical University) |
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| Abstract: | Objective:To design the biological zipper for the animal model of abdominal wall zipper of the miniature pig and test its biocompatibility.Methods:The shape of the biological zipper was designed in line with the size and living habits of the miniature pig,and the demands for animal surgery.According to the series standards of GB/T16886.10-2005,the skin irritation and the skin sensitization experiments were carried out on miniature pigs.Results:The constructed biological zipper was easy to operate,could save... |
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| Keywords: | biological zipper skin irritation skin sensitization biocompatibility |
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