子宫内膜异位症在位及异位子宫内膜Fas、FasL的表达

目的：检测子宫内膜异位症（EM）患者在位及异位内膜中Fas，FasL蛋白的表达， 探讨其在子宫内膜异位症免疫发病机制中的作用。方法：采用免疫组织化学（SP）法分别测定了EM患者在位和异位内膜及正常对照子宫内膜中Fas，FasL蛋白的表达。 结果：1、EM患者在位内膜及正常对照子宫内膜中Fas及FasL的表达均呈周期性改变，增生期呈低水平表达，分泌期表达增高， 两组间同期别比较增生期无显著差异，分泌期EM患者在位内膜的Fas及FasL表达均低于正常对照组；2、异位子宫内膜中的Fas及FasL的表达都呈现低水平或不表达。结论：子宫内膜异位种植可能与Fas及FasL的表达障碍有关。

Expression of Fas and Fas ligand in eutopic and ectopic endometrium of women with endometriosis

Objective: To investigate the effect of Fas/ Fas ligand expression on the pathogenesis of endometriosis( EM ). Methods: Immunohistochemistry was used to assess the expression of Fas and Fas ligand (FasL) in ectopic and eutopic endometrium from patients with EM and those from controls. Results: Eutopic endometrium showed a cyclic change in correlation with the menstrual cycle both in patients with EM and in controls, with Fas/FasL staining found to be increased in secretory phase compared with those in proliferative phase. Although no difference was found between patients with EM and control in their Fas/FasL expression in proliferative phase, there was a decreased level of Fas/ FasL expression in secretory endometria of patients with EM . Notably, expression of the two parameters in ectopic endometrium was observed to be quite low. Conclusion:The low level of Fas and FasL expression in secretory eutopic endometrium and in ectopic endometrium may participate in the ectopic transplantation of endometriosis.