| 五项衰老生化指标的探讨 |
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| 引用本文： | 王荣光,王霞文.五项衰老生化指标的探讨[J].重庆医科大学学报,1992,17(1):31-34. |
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| 作者姓名： | 王荣光 王霞文 |
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| 作者单位： | 重庆医科大学检验系
(王荣光)，重庆医科大学检验系(王霞文) |
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| 摘 要： | 本文观察了2月、10月和24月龄大鼠红细胞膜Na~ -K~ -ATP酶、全血谷胱甘肽过氧化物酶(GSH-PX),红细胞超氧化物歧化酶(SOD)活性及红细胞膜和血浆脂质过氧化物(LP0)水平,结果显示10月龄与2月龄组相比,Na~ -K~ -ATP酶活性增高24.16%.GSH-PX活性增高4o.07%.红细胞膜LPO增高44.44%,血浆LPO增高了102.72%;24月龄与10月龄组相比,Na~ -K~ -ATP酶活性下降45.16%,GSH-PX活性下降了22.3%,SOD活性下降12.32%,而红细胞膜LPO升高30.0%.由此认为上述5项指标可用于评估机体衰老情况
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| 关 键 词： | 大鼠 衰老 超氧化物歧化酶 谷胱甘肽过氧化物酶 脂质过氧化物 Na~ -K~ -ATP酶 |
EVALUATION FOR FIVE INDICATORS FOR AGING |
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| Wang Rongguang,et al.EVALUATION FOR FIVE INDICATORS FOR AGING[J].Journal of Chongqing Medical University,1992,17(1):31-34. |
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| Authors: | Wang Rongguang |
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| Institution: | Wang Rongguang,et al Department of Laboratory Medicine |
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| Abstract: | The following indexes of 2, 10 and 24 months old wistar rats were measured. the activities of RBC membrane Na -K -ATPase, RBC superoxide dismutasc (SOD), blood glutathione. peroxidase (GSH-Px), and the levels of lipid peroxides (EPO) in plasma and RBC membrane From 2 to 10 month-old animals, increases of 24.16%,40.07%, 102.7% and 44.44%in Na-K-ATPase activity, GSH-Px activity, plasma LPO and RBC membra no LPO levels, respectively, were found (P<0.01). In 24 month-old rats, the activity of Na -K -ATPase, SOD and GSH-Px delined by 45.17%, 12.32% and 22.39%, while the LPO level in RBC membrane rose by 30% (P<0.01). These results show that the 5 parameters change with aging, and can serve as biochemical indicators for aging |
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| Keywords: | Rat Aging Superoxide dismutase Glutathione peroxidase Lipid peroxides Na K -ATPase |
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