抗抑郁治疗对卒中后抑郁及神经功能康复的影响

目的探讨氟西汀抗抑郁治疗对卒中后抑郁(PSD)患者的抑郁症状和神经功能康复的影响及其安全性。方法将91例PSD患者随机分为治疗组46例和对照组45例,两组同时应用脑血管病治疗药物,治疗组加用氟西汀治疗。采用汉密尔顿抑郁量表(HAMD)、日常生活自理能力量表(Barthel指数记分)和神经功能缺损程度评定疗效和功能改善状况。结果治疗后治疗组HAMD量表减分率与对照组比较,差异有高度显著性(P<0.01),神经功能缺损程度积分值降低与Barthel评分提高,治疗组优于对照组(P<0.05和P<0.01)。治疗组抑郁症状改善的显效率和神经功能缺损改善的总有效率均显著高于对照组(P<0.001和P<0.05)。氟西汀的主要副反应为失眠、焦虑和恶心。结论氟西汀抗抑郁治疗能明显改善PSD患者的抑郁症状和神经功能,且副反应轻。

Effects of Anti-depression Treatment on Depression Symptom and Rehabilitation of Neural Function of Patients with Post-stroke Depression

Objective To investigate the effects of anti-depression treatment with fluoxetine on depression symptom and rehabilitation of neural function of patients with post-stroke depression (PSD).Methods 91 patients with PSD were randomly divided into treatment group and control group.Treatment group were treated with fluoxetine while control group with no anti-depression drug.The effect were measured by Hamilton depression rating scale (HAMD),activity of daily living scale (Barthel Index) and nerve functional defect degree.Results The score of HAMD after fluoxetine treatment was lower in treatment group than in control group (P<0.01).Nerve functional defect degree and Barthel index were better in treatment group than in control group significantly (P<0.05 or P<0.01).The therapeutic efficacy in depression symptom and nerve functional defect in treatment group was better than that in control group (P<0.001 or P<0.05).The side effects of fluoxetine were insomnia,anxiety and nausea.Conclusion Fluoxetine is effective in treatment of PSD and can improve neurological functions.