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微渗析技术用于金黄膏在大鼠体内经皮渗透性的初步研究
引用本文:张倩,尹忠鹏,赵海南,庞晓晨,马丽,郭林,刘志东,王红.微渗析技术用于金黄膏在大鼠体内经皮渗透性的初步研究[J].天津中医学院学报,2012(3):151-153.
作者姓名:张倩  尹忠鹏  赵海南  庞晓晨  马丽  郭林  刘志东  王红
作者单位:[1]天津市现代中药重点实验室-省部共建国家重点实验室培育基地,300193 [2]天津中医药大学第二附属医院,300150
基金项目:国家自然基金项目(81072818)
摘    要:目的]研究金黄膏在大鼠体内的经皮渗透性。方法]应用经皮微渗析在体取样技术,以Wistar大鼠为模型动物进行实验。微渗析探针的在体回收率采用反向渗析法测定。结果]反向渗析法测定的在体回收率为(32.81±1.33)%。渗析液中的药物稳态流量(J)s为2.73 ng/h,滞后时间(Tla)g为1.50 h。结论]金黄膏中的有效成分在皮肤内有一定的滞留量,该制剂适合经皮给药。

关 键 词:经皮微渗析  盐酸小檗碱  经皮吸收  高效液相色谱法

Preliminary study on permeability of Jinhuanggao by transcutaneous microdialysis in rats in vitro
ZHANG Qian,YIN Zhong-peng,ZHAO Hal-nan,PANG Xiao-chen,MA Li,GUO Lin,LIU Zhi-dong,WANG Hong.Preliminary study on permeability of Jinhuanggao by transcutaneous microdialysis in rats in vitro[J].Journal of Tianjin College of Traditional Chinese Medicine,2012(3):151-153.
Authors:ZHANG Qian  YIN Zhong-peng  ZHAO Hal-nan  PANG Xiao-chen  MA Li  GUO Lin  LIU Zhi-dong  WANG Hong
Institution:1. Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China; 2. Second Affiliated Hospital of Tianjin University of TCM, Tianjin 300150, China)
Abstract:Objective] To study the transeutaneous absorption of Jinhuanggao in rats. Methods] An in vivo sampling technique and transcutaneous microdialysis were used to determine the drug concentration in dermis in rats. The recovery of the microdialysis probe was adopted to assess in vivo according to the retrodialysis method. Results] The recovery in vivo was (32.81 +1.33)% by retrodialysis method. The steady state flux of berberine hydrochloride in dialysate was 2.73 ng/h, and the lag time was 1.5 h. Conclusion] The active ingredient in Jinhuanggao has a good retention amount under the skin. So this preparation is suitable for transdermal drug delivery.
Keywords:cutaneous microdialysis  berberine hydrochloride  transdermal delivery  HPLC
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