| 盐酸小檗碱眼用固体脂质纳米粒的研究 |
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| 引用本文： | 李佳玮,赵海南,郭秀君,Aggrey MO,刘志东,李楠,李琳,潘卫三.盐酸小檗碱眼用固体脂质纳米粒的研究[J].天津中医学院学报,2012(3):157-159. |
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| 作者姓名： | 李佳玮 赵海南 郭秀君 Aggrey MO 刘志东 李楠 李琳 潘卫三 |
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| 作者单位： | [1]天津中医药大学,天津市现代中药重点实验室-省部共建国家重点实验室培育基地,现代中药发现与制剂技术教育部工程研究中心,300193 [2]沈阳药科大学,110016 |
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| 基金项目： | 国家自然基金项目（81001645）; 中国博士后科学基金项目（20090460701） |
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| 摘 要： | 目的]制备盐酸小檗碱固体脂质纳米粒。方法]采用乳化蒸发低温固化法制备盐酸小檗碱纳米粒,采用离体角膜透过实验对其体外进行评价。结果]制备的纳米粒的包封率为51.1%,平均粒径为（19±2）nm,zeta电位为-11.5 mV,表观渗透系数为（1.46±0.45）×10^-6cm/s,与对照组相比增加了16%,差异有统计学意义（P〈0.05）。结论]所用制备工艺简单,可用于制备盐酸小檗碱固体脂质纳米粒。
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| 关 键 词： | 盐酸小檗碱 固体脂质纳米粒 离体角膜透过 |
Preparation of ophthalmic solid lipid nanoparticles loading berberine hydrochioride |
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| LI Jia-wei,ZHAO Hai-nan,GUO Xiu-jun,Aggrey MO,LIU Zhi-dong,LI Nan,LI Lin,PAN Wei-san.Preparation of ophthalmic solid lipid nanoparticles loading berberine hydrochioride[J].Journal of Tianjin College of Traditional Chinese Medicine,2012(3):157-159. |
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| Authors: | LI Jia-wei ZHAO Hai-nan GUO Xiu-jun Aggrey MO LIU Zhi-dong LI Nan LI Lin PAN Wei-san |
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| Institution: | 1. Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China; 2. Shenyang Pharmaceutical University, Shenyang 110016, China) |
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| Abstract: | Objective] To prepare ophthalmic solid lipid nanoparticles loading berberine hydrochloride. Methods] The solid lipid nanoparticles loading berberine hydrochloride were prepared by emulsification-ultrasonic method. The isolated cornea permeation test of the formulation was studied in rabbit. The permeated amount of berberine hydrochloride was determined by high performance liquid chromatography. Results] The entrapment efficiencies of nanoparticle was 51.1%. The average particle size was （19±2） nm. The＇zeta potential was -11.5 mV. The transparent coefficient of the formulation was （1.46±0.45）×10^-6cm/s, increased for 16% when compared with control （P〈0.05）. Conclusion] The preparation technique is simple and stable, which could be used to prepare the solid lipid nanoparticles loading berberine hydrochloride. |
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| Keywords: | berberine hydrochloride solid lipid nanoparticle cornea permeation in vitro |
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