| 川芎嗪抑制瘢痕成纤维细胞增殖及胶原的合成 |
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| 引用本文： | 兰海,王臻,张琳西,郭树忠.川芎嗪抑制瘢痕成纤维细胞增殖及胶原的合成[J].第四军医大学学报,1999,20(11):964-965. |
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| 作者姓名： | 兰海 王臻 张琳西 郭树忠 |
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| 作者单位： | 第四军医大学西京医院整形外科中心,陕西,西安,710033 |
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| 摘 要： | 目的：研究川芎唪治疗增生性瘢痕的机制。方法：对增生性瘢痕成纤维细胞进行体外培养，通过ＭＴＴ法检测成纤维细胞细胞的增殖生，用羟脯氨酸（ＨＰ）比色法测定细胞胶中成含量。结果：ＭＴＴ法显示川芎嗪增生性瘢痕成纤维细胞的增殖活性，可以减少成纤维细胞的胶原合成使细胞形态学发生改变。结论；川芎唪可以抑制增生性瘢痕成纤维细胞的增殖及胶原合成。
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| 关 键 词： | 川芎嗪 瘢痕 成纤维细胞 胶原 |
| 文章编号： | 1000-2790(1999)11-0964-65 |
| 修稿时间： | :1999-06-2 |
Inhibition of Tetramethylpyrazine (TMP) on hypertrophic scar-derived fibroblasts |
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| LAN Hai,WANG Zhen,ZHANG Lin-Xi,Guo Shu-Zhong.Inhibition of Tetramethylpyrazine (TMP) on hypertrophic scar-derived fibroblasts[J].Journal of the Fourth Military Medical University,1999,20(11):964-965. |
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| Authors: | LAN Hai WANG Zhen ZHANG Lin-Xi Guo Shu-Zhong |
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| Abstract: | AIM: To investigate the mechanism of the effect of TL on hypertrophic scar fibroblast. METHODS: Hypertrophic scar derived fibroblasts were cultured in vitro . The proliferation of the fibroblasts is examined by MTT method, and the synthesis of collagen by the fibroblasts is examined by hydroxy proline (HP)colorimetric analysis. RESULTS: The absorbance of MTT method indicated that TL can inhibit the proliferation of hypertrophic scar derived fibroblasts. TL can also reduce the collagen synthesis of the cells, when the fibroblasts are treated with TL. CONCLUSION: TL can inhibit the proliferation and collagen synthesis of the hypertrophic scar derived fibroblasts. |
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| Keywords: | tetramethylpyrazine scar fibroblast collagen |
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