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重型再生障碍性贫血治疗所面临的机遇和挑战
引用本文:蒋白丽,李建平,李文倩,冯建明.重型再生障碍性贫血治疗所面临的机遇和挑战[J].第四军医大学学报,2014(5):35-39.
作者姓名:蒋白丽  李建平  李文倩  冯建明
作者单位:青海省人民医院血液科,青海西宁810007
基金项目:国家自然科学基金(81160071);中国科学院“西部之光”人才培养计划项目(2010年);国家临床重点专科建设项目(2011年)
摘    要:重型再生障碍性贫血(SAA)是由多种因素介导的骨髓造血功能重度衰竭综合征,具有进展快、死亡率高的特点。目前SAA的治疗方法主要为免疫抑制治疗(IST)、异基因造血干细胞移植(Allo-HSCT)和相应的支持治疗。近年来,随着上述治疗方法的不断完善,SAA的长期生存率得到较大的提高,但同时也面临着更大的挑战。

关 键 词:重型再生障碍性贫血  免疫抑制  异基因造血干细胞移植  支持治疗

Opportunities and challenges of the treatment for severe aplastic anemia
JIANG Bai-Li,LI Jian-Ping,LI Wen-Qian,FENG Jian-Ming.Opportunities and challenges of the treatment for severe aplastic anemia[J].Journal of the Fourth Military Medical University,2014(5):35-39.
Authors:JIANG Bai-Li  LI Jian-Ping  LI Wen-Qian  FENG Jian-Ming
Institution:(Department of Hematology, Qinghai Provincial People's Hospital, Xining 810007, China)
Abstract:Severe aplastic anemia is mostly considered as an immune-mediated bone marrow failure syndrome, characterized by rapid progress and high mortality. Until now, immunosuppressive therapy, allogeneic hematopoietic stem cell transplantation and the corresponding support are the main therapeutic methods. With the constant improvement of the therapeutic methods, the long-term survival of severe aplastic anemia has been tremendously boosted. At the same time, the treatment of severe aplastic anemia is facing more and more challenges.
Keywords:severe aplastic anemia  immunosuppressive therapy  allogeneic hematopoietic stem cell transplantation  supportive treatment
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