| 嗅觉功能测查联合磁共振嗅球容积测定对阿尔茨海默病的早期诊断价值 |
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| 引用本文： | 俱西驰,屈秋民,张明,郭晨光,吴谦,杨华,郭峰,罗国刚,金晨旺.嗅觉功能测查联合磁共振嗅球容积测定对阿尔茨海默病的早期诊断价值[J].第四军医大学学报,2009,30(7):636-639. |
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| 作者姓名： | 俱西驰 屈秋民 张明 郭晨光 吴谦 杨华 郭峰 罗国刚 金晨旺 |
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| 作者单位： | 俱西驰,屈秋民,杨华,郭峰,罗国刚,JU Xi-Chi,QU Qiu-Min,YANG Hua,GUO Feng,LUO Guo-Gang(西安交通大学医学院第一附属医院神经内科,陕西,西安,710061);张明,郭晨光,金晨旺,ZHANG Ming,GUO Chen-Guang,JIN Chen-Wang(西安交通大学医学院第一附属医院影像科,陕西,西安,710061);吴谦,WU Qian(西安交通大学医学院流行病学教研室,陕西,西安,710061)
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| 摘 要： | 目的：探讨嗅觉功能测查联合磁共振嗅球容积测定对阿尔茨海默病（AD）的早期诊断价值.方法：用图片介导的气味识别试验分别测定21例AD患者及21例正常对照者的嗅觉觉察阈、嗅觉识别阈;磁共振方法分别测定两组的海马体积及嗅球容积.结果：AD组嗅觉减退,与正常对照组相比,差异有统计学意义（P〈0.05）.AD组简易智能状态检查（MMSE）总分与嗅觉察觉阈、嗅觉识别阈之间呈负相关（r=-0.50,r=-0.54,P〈0.01）.AD组海马体积较正常对照组明显减少,两组比较差异有统计学意义（P〈0.01）.AD组海马体积与MMSE评分呈正相关（r=0.45,P〈0.05）.AD组嗅球容积实测值及经颅腔容积校正值均较正常对照组缩小（P〈0.01）,AD组嗅球容积与海马体积、MMSE评分呈正相关（r=0.72,P〈0.01;r=0.50,P〈0.05）,与嗅觉察觉阈及嗅觉识别阈呈负相关（为r=-0.63,r=-0.54,P〈0.05）.结论：嗅觉功能测查联合磁共振嗅球容积测定可帮助诊断早期AD.
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| 关 键 词： | 嗅觉功能 磁共振 海马体积 嗅球容积 阿尔茨海默病 |
Early diagnostic value of olfactory function measurement combined with MRI olfactory bulb volume measurement to Alzheimer's disease |
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| JU Xi-Chi,QU Qiu-Min,ZHANG Ming,GUO Chen-Guang,WU Qian,YANG Hua,GUO Feng,LUO Guo-Gang,JIN Chen-Wang.Early diagnostic value of olfactory function measurement combined with MRI olfactory bulb volume measurement to Alzheimer's disease[J].Journal of the Fourth Military Medical University,2009,30(7):636-639. |
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| Authors: | JU Xi-Chi QU Qiu-Min ZHANG Ming GUO Chen-Guang WU Qian YANG Hua GUO Feng LUO Guo-Gang JIN Chen-Wang |
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| Institution: | JU Xi-Chi1,QU Qiu-Min1,ZHANG Ming2,GUO Chen-Guang2,WU Qian3,YANG Hua1,GUO Feng1,LUO Guo-Gang1,JIN Chen-Wang21Department of Neurology,2Department of Iconography,First Affiliated Hospital,3Department of Epidemiology,Medical School of Xi'an Jiaotong University,Xi'an 710061,China |
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| Abstract: | AIM:To study the early diagnostic value of olfactory function measurement combined with MRI olfactory bulb volume measurement to Alzheimer's disease(AD).METHODS:Olfactory function measurement with picture-based odor identification test was conducted in 21 patients with AD and 21 healthy elderly subjects as control.Olfactory bulb volume and hippocampal volume in the two groups were measured with MRI.RESULTS:Olfactory function was significantly impaired in AD group compared with that in healthy control group(... |
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| Keywords: | olfactory function measurement magnetic resonance imaging olfactory bulb volume hippocampal volume alzheimer's disease |
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