| 巨噬细胞融合瘤苗对大鼠骨肉瘤的主动性免疫治疗 |
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| 引用本文： | 郝新保,范清宇,张殿忠,裘秀春,殷剑宁,张惠中,王晓宁.巨噬细胞融合瘤苗对大鼠骨肉瘤的主动性免疫治疗[J].第四军医大学学报,1999,20(12):1042-1044. |
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| 作者姓名： | 郝新保 范清宇 张殿忠 裘秀春 殷剑宁 张惠中 王晓宁 |
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| 作者单位： | 第四军医大学唐都医院全军骨肿瘤研究所,陕西西安,710038 |
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| 基金项目： | 全军“九五”医药卫生科研基金!96Z048 |
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| 摘 要： | 目的：探讨融合瘤苗在骨肉瘤免疫治疗中的应用潜力。方法：用ＵＭＲ１０６细胞系建立大鼠骨肉瘤动物模型，然后将该细胞系与大鼠巨噬细胞融合作为瘤苗应用于荷瘤大鼠，观察其抑制肿瘤生长和肺转移的效果。结果：在治疗６ＯＫ时治疗组和对照组相比，瘤重明显减小（Ｐ〈０．０１）；肺转移发生率降低（Ｐ〈０．０１）。结论：骨肉瘤细胞与巨噬细胞的两便瘤苗可望的骨肉瘤的治疗中发挥作用。
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| 关 键 词： | 骨肉瘤 免疫治疗 巨噬细胞 癌症疫苗 |
| 文章编号： | 1000-2790(1999)12-1042-44 |
| 修稿时间： | 1999年9月30日 |
Immunotherapy of rat osteosarcoma using tumor vaccine from fusion of macrophages with osteosarcoma cells |
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| HAO Xin-Bao,FAN Qing-Yu,ZHANG Dian-Zhong,QIU Xiu-Chun,YIN Jian-Ning,ZHANGHui-Zhong,WANG Xiao-Ning.Immunotherapy of rat osteosarcoma using tumor vaccine from fusion of macrophages with osteosarcoma cells[J].Journal of the Fourth Military Medical University,1999,20(12):1042-1044. |
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| Authors: | HAO Xin-Bao FAN Qing-Yu ZHANG Dian-Zhong QIU Xiu-Chun YIN Jian-Ning ZHANGHui-Zhong WANG Xiao-Ning |
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| Abstract: | AIM: To eva1uate the therapeutic effectiveness offusion tumor vaccine in osteosarcoma treatment. METH-ODS: The UMRlO6 cell line was injected subcutaneously intothe SD rat flank to establish the animal model and was fusedwith macrophages to obtain the tumor vaccine. Then thetherapeutic effectiveness of the tumor vaccine to the originaltumor and lung metastasis in the animal model was observed.RESULTS: 6 weeks after the treatment with tumor vaccine,the size of the original tumor and the rate of lung metastasisin the therapeutic group were both largely reduced comparewith those in control groups (P < O. O1 ). CONCLUS1ON:The fusion tumor vaccine perhaps can be used in the clinicaltreatment of osteosarcoma. |
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| Keywords: | osteosarcoma immunotherapy macrophages cancer vaccine |
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