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前列腺癌Survivin和p53蛋白表达的相关性
引用本文:张剑,王禾,秦卫军,张更,杨晓剑,张波,宋斌,周宇,张世睿,阎宏亮.前列腺癌Survivin和p53蛋白表达的相关性[J].第四军医大学学报,2005,26(3):251-253.
作者姓名:张剑  王禾  秦卫军  张更  杨晓剑  张波  宋斌  周宇  张世睿  阎宏亮
作者单位:第四军医大学西京医院泌尿外科,陕西,西安,710033
摘    要:目的:研究Survivin和p53蛋白在前列腺癌组织的 表达及生物学意义,并探讨其相关性.方法:采用免疫组化的 方法检测55例前列腺癌组织中Survivin和p53蛋白的表达. 结果:Survivin和p53蛋白在前列腺癌组织中的阳性表达例数 分别为43(78.18%)和27(49.09%),并且均与肿瘤的病理 学分级、临床分期相关(P<0.05).在前列腺癌中两种蛋白的 表达密切相关(r=0.629).结论:Survivin蛋白的表达和p53 突变对凋亡抑制的协同作用可能在前列腺癌的发生发展过程 中起关键作用.

关 键 词:Survivin蛋白  p53蛋白  前列腺癌  免疫组化
文章编号:1000-2790(2005)03-0251-03
修稿时间:2004年7月13日

Relationship and expression of survivin and p53 in prostatic carcinoma
ZHANG Jian,WANG He,QIN Wei-Jun,ZHANG Geng,YANG Xiao-Jian,ZHANG Bo,SONG Bin,ZHOU Yu,ZHANG Shi-Rui,YAN Hong-Liang.Relationship and expression of survivin and p53 in prostatic carcinoma[J].Journal of the Fourth Military Medical University,2005,26(3):251-253.
Authors:ZHANG Jian  WANG He  QIN Wei-Jun  ZHANG Geng  YANG Xiao-Jian  ZHANG Bo  SONG Bin  ZHOU Yu  ZHANG Shi-Rui  YAN Hong-Liang
Institution:ZHANG Jian,WANG He,QIN Wei-Jun,ZHANG Geng,YANG Xiao-Jian,ZHANG Bo,SONG Bin,ZHOU Yu,ZHANG Shi-Rui,YAN Hong-Liang Department of Urology,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China
Abstract:AIM: To investigate the expression of surviving and p53 in the tissues of prostatic carcinoma and to evaluate the relationship between survivin and p53. METHODS: The expression of survivin and p53 in 55 patients with prostatic carcinoma were examined using immunohistochemical method. RESULTS: The positive cases of survivin and p53 in prostatic carcinoma were 43 (78.18%) and 27 (49.09%) , respectively. The positive rate of survivin and p53 was strongly associated with pathological grades and clinical stages (P<0.05). The expression of survivin was correlated with p53 (r=0.629). CONCLUSION: The inhibition of apoptosis caused by the cooperation of surviving and loss of p53 may play a pivotal role in tumorigenneis and tumor progression in prostatic carcinoma.
Keywords:survivn  p53  prostatic neoplasms  immunohistochemistry
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