复发性自然流产与解脲支原体、沙眼衣原体和弓形虫感染的关系

目的:探讨复发性自然流产(RSA)与解脲支原体(Uu)、沙眼衣原体(Ct)和弓形虫(Tox)感染之间的关系.方法:用聚合酶链反应(PCR)法检测214例自然流产患者宫颈分泌物中Uu和Ct、采用酶联免疫吸附试验(ELISA)法检测静脉血中Tox IgM;同样对72例自愿人工流产者进行其检测.结果:在214例自然流产患者中Uu,Ct和Tox感染率分别为26.6%,22.9%和10.8%,其中Uu和Ct合并感染率为10.3%,对照组其Uu,Ct和Tox感染率分别为5.6%,4.2%和2.8%,其中Uu和Ct合并感染率为2.8%,两组间有显著性差异(P<0.05).同时自然流产次数≥3次者其Uu,Ct和Tox感染率38.5%,34.6%,19.2%明显高于≤2次的对应感染率22.8%,19.1%,6.1%(P<0.05).结论:Uu,Ct和Tox感染与RSA密切相关.

Relationship between recurrent spontaneous abortion and Ureaplasma urealyticum, Chlamydia trachomatis and Toxoplasma gondii infection

AIM: To probe into the relationship between recurrent spontaneous abortion (RSA) and Ureaplasma urealyticum (Uu), Chlamydia trachomatis (Ct) and Toxoplasma gondii (Tox). METHODS: The technique of polymerase chain reaction (PCR) was applied to detect Uu and Ct in cervical secretion and enzyme linked immonosorbent assay (ELISA) was applied to detect Tox IgM in the serum of 214 spontaneous abortions and controls who had volunteered artificial abortion. RESULTS: The positive rate of Uu, Ct and Tox infection was 26.6%, 22.9% and 10.8% respectively, and the positive rate of Uu and Ct coinfection was 10.3% in the 214 spontaneous abortions, and that of the control group was 5.6%,4.2%,2.8% and 2.8% respectively. The counterpart rates of the two groups had significant difference by statistics (P<0.05). The positive rate of Uu, Ct and Tox (38.5%, 34.6%, 19.2%) was higher in the group of RSA than that of the group who had RSA less than three times (22.8%,19.1%,6.1%) (P<0.05). CONCLUSION: The infection of Uu, Ct and Tox is closely related to the RSA.