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异体脱钙骨基质骨粒骨水泥骨形态发生蛋白复合材料的成骨诱导活性
引用本文:周勇,范清宇,蒋维中,蔡和平,文艳华.异体脱钙骨基质骨粒骨水泥骨形态发生蛋白复合材料的成骨诱导活性[J].第四军医大学学报,1999,20(12):1085-1087.
作者姓名:周勇  范清宇  蒋维中  蔡和平  文艳华
作者单位:1. 第四军医大学唐都医院全军骨科中心,陕西西安,710038
2. 西安交通大学材料学院
摘    要:目的:探讨异体脱钙骨基质(DBM)骨粒、骨水泥(BC)及重组人骨形态发生蛋白-2(rhBMP-2)复合骨制损修复材料成骨诱导活性。方法:小鼠股部股袋内植入复合材料,不同时间分别取材HE染色观察复合骨制损修复材料的异位诱导成骨活笥;检测不同复合质量比的复合材料的聚合温度。结果:第7日时材料外周即形成间充质组织包膜,并沿材料不规则裂隙向植入材料内部长入间充质组织。第14日间充质组织继续大量长入且逐渐深

关 键 词:骨诱导  脱钙骨基质  重组人骨形态发生蛋白-2  骨粘合剂
文章编号:1000-2790(1999)12-1085-87
修稿时间:1999年9月30日

Bone induction of compound material of decalcified bone matrix with rhBMP-2 impregnated bone cement
ZHOU Yong, FAN Qing-Yu, JIANG Wei-Zhong, CAI He-Ping, WEN Yan-Hua.Bone induction of compound material of decalcified bone matrix with rhBMP-2 impregnated bone cement[J].Journal of the Fourth Military Medical University,1999,20(12):1085-1087.
Authors:ZHOU Yong  FAN Qing-Yu  JIANG Wei-Zhong  CAI He-Ping  WEN Yan-Hua
Abstract:A1M: To evaluate the capacity of bone inductionof the compound material of decalcified bone matrix (DBM)particles with rhBMP-2 impregnated bone cement. METH-ODS: The compound material was embedded into mousemuscle at cruro-inguinal part and the tissues at site were ob-tained by surgery at different intervals, which were stainedwith HE method to observe the bone induction capacity of thecompound material. In the mean time, the polymerizing tem-'perature of the compound with three materials at differentweight ratio was compared. RESULTS: Mesenchymal tissuesaround the compound material was found 7 days after embed-ding, which grew into the mature bone tissues with the pas-sage of time. The polymerizing temperature had no influenceon the bone induction capacity of the compound. CONCLU-SION: The compound material of DBM particles with bonecement impregnated rhBMP-2 is able to induce the prolifera-tion, migration and formation of new bone tissues and thenew bone tissues can absorb DBM particles gradually.
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