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降钙素基因相关肽对心肌细胞缺血缺氧状态下胞内钙的影响
引用本文:商立军,臧益民,王春梅,臧伟进,董明清,陈贤明,王四旺. 降钙素基因相关肽对心肌细胞缺血缺氧状态下胞内钙的影响[J]. 医学争鸣, 2000, 21(4): 408-410
作者姓名:商立军  臧益民  王春梅  臧伟进  董明清  陈贤明  王四旺
作者单位:1. 第四军医大学基础部,生理学教研室,陕西,西安,710033
2. 第四军医大学基础部,中心实验室,陕西,西安,710033
3. 西安医科大学心血管生理药理研究室
4. 第四军医大学,西京医院耳鼻咽喉科
5. 第四军医大学,药物研究所
基金项目:国家自然科学基金资助项目!(39970273)
摘    要:目的 观察降钙素基因相关肽(CGRP)对急性分离心肌细胞在模拟缺血缺氧状态下胞内钙的影响。方法 急性分离心肌细胞在模拟缺血缺氧状态下,以Fluo-3作为钙指示剂,用共聚焦显微镜测定胞内钙的变化。结果 急性缺血缺氧时,心肌细胞胞内钙浓度降低,加入CGRP后,钙浓度恢复;先加入CGRP,再在缺血缺氧的条件下,胞内钙浓度基本保持不变,结论 CGRP可恢复因急性缺血缺氧而导致的细胞内钙浓度降低。

关 键 词:降钙素基因相关肽 缺氧 CGRP 心肌细胞 心肌缺血 胞内钙 Fuo-3
修稿时间::

Effect of CGRP on intracellular calcium concentration in cardiomyocytes under is chemia and hypoxia conditions
SHANG Li-Jun,ZANG Yi-Min,WANG Chun-Mei,ZANG Wei-Jin,DONG Ming-Qing,CHEN Xian-Ming,WANG Si-Wang. Effect of CGRP on intracellular calcium concentration in cardiomyocytes under is chemia and hypoxia conditions[J]. Negative, 2000, 21(4): 408-410
Authors:SHANG Li-Jun  ZANG Yi-Min  WANG Chun-Mei  ZANG Wei-Jin  DONG Ming-Qing  CHEN Xian-Ming  WANG Si-Wang
Abstract:AIM To observe the effect of CGRP on intracellular calcium concentration in acute isolated cardiomyocytes under ischemia and hypoxia conditions. METHODS The acute isolated cardiomyocytes were rendered ischemia and hypoxia, and intracellular calcium concentration was measured with the fluorescent Ca 2+ indicator Fluo 3 and laser scanning confocal microscopy. RESULTS Acute hypoxia and ischemia induced the decrease of intracellular calcium concentration in acute isolated cardiomyocytes, while CGRP could reverse these changes. But the intracellular calcium concentration almost remained steady when the acute isolated cardiomyocytes were put under acute hypoxia and ischemia conditions following the adding of CGRP. CONCLUSION CGRP can reverse the decrease of intracellular calcium concentration caused by acute hypoxia and ischemia.
Keywords:CGRP  ischemia  hypoxia  cardiomyocytes  intracellular calcium  Fluo-3
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