| 唐古特大黄多糖对小鼠急性肝损伤的保护作用 |
| |
| 引用本文： | 刘莉,李保莉.唐古特大黄多糖对小鼠急性肝损伤的保护作用[J].第四军医大学学报,1999,20(6):549-551. |
| |
| 作者姓名： | 刘莉 李保莉 |
| |
| 作者单位： | [1]第四军医大学基础中药理学教研室西安 [2]医学院 |
| |
| 摘 要： | 目的：观察唐古特大黄多糖（ＴＭＰ）对小鼠急性肝损伤的保护作用及探讨ＴＭＰ对肝损伤的保护机理。方法：小鼠６０只，随机分６组，生理盐水正常对照组，药物模型组，生理盐水模型对照组和３个给药组，每组按要求分别用ＣＣｌ４ １５６ｍｇ／ｋｇ，Ｄ－Ｇａｌ－Ｎ８００ｍｇ／ｋｇ，ＴＡＡ５００ｍｇ／ｋｇ腹腔注射（ｉｐ），造成小鼠急性肝损伤，以ＴＭＰ１００ｍｇ／ｋｇ，２００ｍｇ／ｋｇ，４００ｍｇ／ｋｇ×５ｄ灌胃，用硫代
|
| 关 键 词： | 唐古特大黄多糖 肝损伤 保护作用 中药 |
Effects of tangufican maxim polysaccharides in acute liver injury of mice |
| |
| LIU Li,LI BaoLi,ZHOU SiYuan,MEI QiBing,ZHAO DeHua,CAO ZhiXian.Effects of tangufican maxim polysaccharides in acute liver injury of mice[J].Journal of the Fourth Military Medical University,1999,20(6):549-551. |
| |
| Authors: | LIU Li LI BaoLi ZHOU SiYuan MEI QiBing ZHAO DeHua CAO ZhiXian |
| |
| Institution: | LIU Li1,LI BaoLi2,ZHOU SiYuan1,MEI QiBing1,ZHAO DeHua1,CAO ZhiXian3 1Department of Pharmacology,Faculty of Preclinical Medicine,Fourth Military Medical University,Xi'an 710033,Shaanxi Province,China,2Yanan Medical College,3Department of Pha |
| |
| Abstract: | AIM: To investigate the effects of TMP on acute liver injury in mice and to study the protective mechanism of TMP in mice with acute liver injury. METHODS: Three acute liver injury models of mice were made by using CCl4 (156 mg/kg), DGalN (800 mg/kg) and TAA (550 mg/kg) ip respectively, following TMP 100 mg/kg, 200 mg/kg and 400 mg/kg ig for 5 days respectively. RESULTS: The increasing trend of AST and ALT in serum and MDA in liver tissue was significantly inhibited. CONCLUSION: TMP can protect mice against CCl4, DGalN or TAAinduced acute liver injury. |
| |
| Keywords: | TMP acute liver injury model mice liver diseases traditional Chinese medicine |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
