黄芪注射液对肺结核患者T细胞亚群的影响及近期疗效

目的：探讨黄芪液对肺结核患者细胞免疫功能的影响及近期疗效。方法：将５６例初治活动性肺结核患者随机分为治疗组和对照组,在相同痨方案基础上,治疗组加用黄芪注射液２０ｍＬ１次／ｄ静脉滴注,分别在治疗前后采空血检测外周血中Ｔ淋巴细胞亚群ＣＤ３,ＣＤ４和ＣＤ８,以痰涂片及治疗前后胸一改变考核疗效。结果：治疗组与治疗前及对照组治疗后比较ＣＤ３,ＣＤ４显著升高,ＣＤ８变化不大,肺部病灶吸收率治疗组显著高于对照组

Effect of Astragalus root injection on T cell subsets of pulmonary tuberculosis patients and its short-term curative effect

AIM: To observe the effect of Astragalus root injection on cellular immunity of pulmonary tuberculosis patients and its short term curative effect. METHODS: 56 active pulmonary tuberculosis patients were divided into therapy group and control group at random. While on the same antiphthisic chemotherapy program, Astragalus root injection (20 mL/d, iv gtt) was added in the therapy group. The therapy effect was assessed by the determination of fasting peripheral blood T lymphocyte subpopulation CD3, CD4 and CD8 pre and post therapy, by the sputum smear and by the chest X ray change pre and post therapy. RESULTS: The levels of CD3, CD4 post therapy were significantly higher than those pre therapy in therapy group ( P <0.01). No significant difference was found in CD8. The absorption rate of nidus in pulmonary therapy group was significantly higher than that in control group, and so were the sputum negative conversion rate and the cavity shrink or close rate ( P < 0.05 ). CONCLUSION: Astragalus root injection, combined with antiphthisic chemotherapy, can enhance the cellular immunity of lung tuberculosis, speed up the focal healing and is helpful in sputum negative conversion.