注射用盐酸氨溴索祛痰作用的疗效和安全性评价 |
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引用本文: | 赵磊,文爱东,吴昌归,史皆然,简文,吴寅,张三奇,石茹.注射用盐酸氨溴索祛痰作用的疗效和安全性评价[J].第四军医大学学报,2004,25(2):189-192. |
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作者姓名: | 赵磊 文爱东 吴昌归 史皆然 简文 吴寅 张三奇 石茹 |
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作者单位: | 第四军医大学西京医院,药剂科,陕西,西安,710033;第四军医大学西京医院,呼吸内科,陕西,西安,710033 |
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摘 要: | 目的 :评价注射用盐酸氨溴索祛痰作用的临床疗效及安全性 .方法 :以沐舒坦注射液为对照药 ,采用随机单盲、平行对照的试验方法 ,试验组与对照组各 1 8例 .试验组给予注射用盐酸氨溴索 ,每次 30mg ,对照组给予沐舒坦注射液 ,每次 30mg ,均为缓慢iv ,每日 2次 ,疗程 5 7d .结果 :两组总有效率分别为 89%和 94 % ,试验组与对照组的药物不良反应发生率分别为 1 1 %和 6 % .两组总有效率和不良反应发生率均无统计学差异 (P >0 .0 5 ) .结论 :注射用盐酸氨溴索是一种安全、有效的祛痰药物
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关 键 词: | 盐酸氨溴索 沐舒坦 祛痰药 |
文章编号: | 1000-2790(2004)02-0189-04 |
修稿时间: | 2003年6月4日 |
Evaluation of efficacy and safety of injective ambroxol hydrochloride |
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Abstract: | AIM: To evaluate the efficacy and safety of injective ambroxol hydrochloride. METHODS: Clinical experiment was carried out by means of single blind, randomized, paralleled and controlled way. Thirty six patients were divided into experiment group and control group ( n =18) randomly. The patients in the experiment group received intravenous injection of mucosolvan, while the patients in the control group received ambroxol hydrochloride, with a dosage of 30 mg bid for 5-7 days each. The clinical efficacy rates and the adverse drug reaction rates were compared. RESULTS: The comprehensive clinical efficacy rates of the two groups were 89% and 94%, respectively. The adverse drug reaction rates of the experiment group and control group were 11% and 6%, respectively. There were no statistical difference in clinical efficacy and adverse drug reaction between two groups. CONCLUSION: Injective ambroxol hydrochloride is an effective and safe expectorant. |
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Keywords: | ambroxol hydrochloride mucosolvan expectorant |
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