术前介入化疗治疗巨块型宫颈癌52例疗效分析 |
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引用本文: | 于月成,汪海丹,辛晓燕,李贵容,赵海波,王滨.术前介入化疗治疗巨块型宫颈癌52例疗效分析[J].第四军医大学学报,2004,25(6):557-559. |
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作者姓名: | 于月成 汪海丹 辛晓燕 李贵容 赵海波 王滨 |
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作者单位: | 1. 第四军医大学西京医院妇产科,陕西,西安,710033 2. 解放军82医院肿瘤中心,江苏,淮安,223001 |
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摘 要: | 目的: 研究和探索术前新辅助介入化疗治疗巨块型宫颈癌的方法和可行性,评价其对宫颈癌的治疗效果及对根治术的辅助价值. 方法: 选取1998-09/2000-01就诊的52例巨块型宫颈癌患者,术前采用顺铂50 mg/m2、5-氟尿嘧啶1000 mg/m2、丝裂霉素20 mg/m2方案进行子宫动脉介入化疗2~3疗程,并对有手术适应证者及时实行宫颈癌根治术. 结果: 介入化疗后12例完全缓解(CR),28例部分缓解(PR),8例无变化(NR),4例疾病进展(PD),总有效率为77%,与化疗前相比肿瘤体积显著缩小(P<0.05),对其中50例患者成功实施了宫颈癌根治术. 术后病理发现淋巴结转移者中CR1例,PR4例,NR或PD8例,均为盆腔淋巴结转移. 所有患者均未发生严重的化疗或手术并发症. 结论: 术前介入化疗可缩小宫颈癌病灶,并能减少淋巴结转移和复发,是一种安全有效的治疗方法.
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关 键 词: | 宫颈肿瘤 化学栓塞 治疗性 |
文章编号: | 1000-2790(2004)06-0557-03 |
修稿时间: | 2003年11月12 |
Efficiency of intra-arterial neoadjuvant chemotherapy before radical excision in 52 patients with cervical cancer |
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Abstract: | AIM: To explore the feasibility and therapeutic efficiency of intra arterial neoadjuvant chemotherapy before radical excision in patients with cervical cancer. METHODS: Fifty two female patients with cervical cancer were enrolled into the study and were treated with a 2 3 course of intra arterial neoadjuvant chemotherapy immediately after the pathological diagnosis. The regime included 50 mg/m 2 DDP, 1000 mg/m2 5 FU and 20 mg/m 2 MMC. Then radical excision was performed in those who were good for the operation. RESULTS: Complete recovery (CR) was acquired in 12 patients and partial recovery (PR) in 28 patients. The total response rate was 76.9%, with no recovery (NR) in 8 and progressed disease (PD) in 4 of 52 cases after 2 courses of intra arterial neoadjuvant chemotherapy. The tumor size reduced significantly ( P <0.05) after neoadjuvant therapy and the radical excision was preformed successfully in 50 patients. Pathological examination revealed pelvic lymphatic metastasis in 1 of 12CR, 4 of 28 PR, and 8 of NR or PD. No serious side effects related to the chemotherapy or operation were observed in all the patients. CONCLUSION: Intra arterial neoadjuvant chemotherapy before radical excision not only is helpful for operation but also can reduce metastasis and recurrence. It can extend patients' survival time and improve life quality. |
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Keywords: | cervix neoplasms chemoembolization therapeutic |
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