| 大豆异黄酮对去势雄性大鼠腰椎和胫骨骺端骨小梁变化的影响 |
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| 引用本文： | 赵静,张哲鹏,王辛,陈健康,于军,曲萍,张学策,铁茹.大豆异黄酮对去势雄性大鼠腰椎和胫骨骺端骨小梁变化的影响[J].第四军医大学学报,2009(24). |
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| 作者姓名： | 赵静 张哲鹏 王辛 陈健康 于军 曲萍 张学策 铁茹 |
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| 作者单位： | 第四军医大学口腔医学系七队;第四军医大学预防医学系一队;第四军医大学基础部教学实验中心; |
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| 摘 要： | 目的:研究大豆异黄酮对骨质疏松的治疗效应.方法:24只雄鼠随机分假手术组(A组)、双侧睾丸去除术的去势组(B组),实施双侧睾丸去除术并用大豆异黄酮治疗组(C组).术后8wkHE染色观察腰椎和胫骨骨小梁的组织学改变及大豆异黄酮作用.结果:A组相比,B组SD大鼠腰椎和胫骨骨小梁宽度变窄,骨小梁间距变宽,骨小梁占视野面积比降低,而且发生多处断裂,C组与B组比较发现其有所改善,并有新的软骨生成.结论:大豆异黄酮对双侧去势雄性SD大鼠的骨质疏松有一定的治疗作用.
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| 关 键 词： | 去势雄鼠 腰椎 胫骨 骨小梁 大豆异黄酮 骨质疏松 |
Effects of soy isoflavones on the trabecula of lumbar and tibial epiphyseal extremity in bilateral castrated male rats |
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| ZHAO Jing,ZHANG Zhe-Peng,WANG Xin,CHEN Jian-Kang,YU Jun,QU Ping,ZHANG Xue-Ce,TIE Ru Seventh Teams.Effects of soy isoflavones on the trabecula of lumbar and tibial epiphyseal extremity in bilateral castrated male rats[J].Journal of the Fourth Military Medical University,2009(24). |
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| Authors: | ZHAO Jing ZHANG Zhe-Peng WANG Xin CHEN Jian-Kang YU Jun QU Ping ZHANG Xue-Ce TIE Ru Seventh Teams |
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| Institution: | ZHAO Jing1,ZHANG Zhe-Peng2,WANG Xin1,CHEN Jian-Kang3,YU Jun3,QU Ping3,ZHANG Xue-Ce3,TIE Ru3 1Seventh Teams,Department of Stomatology,2First Teams,Department of Preventive Medicine,3Center of Teaching & Experiment,School of Basic Medicine,Fourth Military Medical University,Xi'an 710033,China |
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| Abstract: | AIM:To investigate the therapeutic effects of soybean isoflavones on osteoporosis.METHODS:Twenty-four male rats were randomly assigned into 3 groups:group A,as the control,were implemented sham surgery on the bilateral testicular;group B were treated with bilateral testicular ablation;group C were animals with bilateral testicular ablation and treated with soybean Isoflavones.After 8-week treatment,the rats were sacrificed and the the trabecula of lumbar and tibial epiphyseal extremity was observed and the ... |
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| Keywords: | bilateral castration male lumbar tibial epiphyseal extremity trabecular bone soy isoflavones osteoporosis |
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