| Roux-en-Y胃旁路术改善非肥胖型糖尿病大鼠糖脂代谢 |
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| 引用本文： | 李桢,李东飞,张红亚,梁炜,戴景兴,原林.Roux-en-Y胃旁路术改善非肥胖型糖尿病大鼠糖脂代谢[J].第四军医大学学报,2009(23). |
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| 作者姓名： | 李桢 李东飞 张红亚 梁炜 戴景兴 原林 |
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| 作者单位： | 南方医科大学基础医学院临床解剖学研究所国家级重点学科;新乡医学院第二附属医院河南省精神生物医学重点实验室; |
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| 基金项目： | 国家重点基础研究发展计划(2007CB512700) |
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| 摘 要： | 目的:观察Roux-en-Y胃旁路术对非肥胖糖尿病Goto-Kakizaki(GK)大鼠血糖和血脂代谢的影响.方法:18只GK大鼠随机等分为Roux-en-Y胃旁路手术组(RYGB组)、假RYGB组和对照组;观察手术后1,2,4,12 wk各组血清葡萄糖和胰岛素变化,观察手术后4,12 wk血清总胆固醇、三酰甘油和游离脂肪酸含量以及口服葡萄糖耐量试验和口服葡萄糖后胰岛素变化.结果:手术后各组摄食量无差异(F=1.222,P=0.322);手术后RYGB组空腹血糖较假RYGB组和对照组明显下降(F=10.064,P=0.002);RYGB组空腹胰岛素较假RYGB组和对照组明显升高(F=56.138,P=0.000).手术后RYGB组4,12 wk口服葡萄糖耐量试验血糖值曲线下面积明显减少(F=4.738,P=0.016),与假RYGB组和对照组比较均存在统计学差异(P=0.039,P=0.028);胰岛素值曲线下面积明显增加(F4 wk=192.112,P=0.000;F12 wk=228.284,P=0.000).RYGB组术后血清总胆固醇显著下降(P<0.05);血清三酰甘油和游离脂肪酸在RYGB组均明显降...
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| 关 键 词： | 胃旁路术 2型糖尿病 动物 糖代谢 脂质代谢 |
Effects of gastric bypass on carbohydrate and lipid metabolism in non-obese diabetic Goto-Kakizaki rats |
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| LI Zhen,LI Dong-Fei,ZHANG Hong-Ya,LIANG Wei,DAI Jing-Xing,YUAN Lin Institute of Clinical Anatomy,School of Basic Medicine,Southern Medical University,Guangzhou ,China,Second Affiliated Hospital,Xinxiang Medical College,Henan Provincial Key Psychiatric Laboratory,Xinxiang.Effects of gastric bypass on carbohydrate and lipid metabolism in non-obese diabetic Goto-Kakizaki rats[J].Journal of the Fourth Military Medical University,2009(23). |
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| Authors: | LI Zhen LI Dong-Fei ZHANG Hong-Ya LIANG Wei DAI Jing-Xing YUAN Lin Institute of Clinical Anatomy School of Basic Medicine Southern Medical University Guangzhou China Second Affiliated Hospital Xinxiang Medical College Henan Provincial Key Psychiatric Laboratory Xinxiang |
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| Institution: | LI Zhen1,LI Dong-Fei1,ZHANG Hong-Ya2,LIANG Wei2,DAI Jing-Xing1,YUAN Lin1 1Institute of Clinical Anatomy,School of Basic Medicine,Southern Medical University,Guangzhou 510515,China,2Second Affiliated Hospital,Xinxiang Medical College,Henan Provincial Key Psychiatric Laboratory,Xinxiang 453002 |
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| Abstract: | AIM:To observe the effects of gastric bypass on carbohydrate and lipid metabolism in non-obese diabetic Goto-Kakizaki(GK) rats.METHODS:Eighteen male GK rats were randomly allocated into 3 groups;Roux-en-Y gastric bypass(RYGB) group,sham RYGB group(sham-RYGB) and pair-fed control group.Each group was monitored for fasting glucose,oral glucose tolerance and insulin as well as plasma levels of cholesterol,triglycerides,and free fatty acids on 1st,2nd,4th,12th weeks,post-operatively.RESULTS:No significant diffe... |
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| Keywords: | gastric bypass 2 type diabetes mellitus animals carbohydrate metabolism lipid metabolism |
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