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川芎嗪和/或阿魏酸对麻醉狗血流动力学的不同效应
引用本文:任平,焦凯,李月彩,黄熙,臧益民,王跃民.川芎嗪和/或阿魏酸对麻醉狗血流动力学的不同效应[J].第四军医大学学报,1999,20(9):797-799.
作者姓名:任平  焦凯  李月彩  黄熙  臧益民  王跃民
作者单位:1. 第四军医大学,西京医院老年病科
2. 第四军医大学,唐都医院内分泌科
3. 第四军医大学,基础部生理教研室,陕西,西安,710033
摘    要:目:观察磷酸川芎嗪(TMPP)和阿魏酸钠(SF)分别和联合应用对狗的急性血流动力学效应,了解它们的母方川芎和当归这一著名药对联用的作用原理.方法:麻醉开胸狗静脉单独或联合注射TMPP和SF.结果:静脉单独给药时,TMPP剂量依赖性地增加左室收缩压(LVSP)、左室压上升最大速率(+LVdP/dtmax)、冠脉血流量(CBF)、心率(HR)和降低平均动脉压(mAoP),SF则不产生明显的血流动力学效

关 键 词:阿魏酸  川芎嗪  血液动力学  联合用药
修稿时间:1999-02-04

Different effects of tetramethylpyrazine and/or ferulate on hemodynamics in anesthetized dogs
REN Ping,JIAO Kai,LI Yue-Cai,HUANG Xi,ZANG Yi-Min,WANG Yao-Min.Different effects of tetramethylpyrazine and/or ferulate on hemodynamics in anesthetized dogs[J].Journal of the Fourth Military Medical University,1999,20(9):797-799.
Authors:REN Ping  JIAO Kai  LI Yue-Cai  HUANG Xi  ZANG Yi-Min  WANG Yao-Min
Abstract:AIM: To observe the different effects of tetramethylpyrazine (TMPP) and sodium ferulate (SF) used separately or in combination on hemodynamics in anesthetized dogs. METHODS: TMPP and SF were injected intravenously into the anesthetized dogs separately or in combination. RESULTS: When given alone, TMPP increased left ventricular systolic pressure (LVSP), peak positive first derivative of left ventricular (+LVdP/dt), coronary blood flow (CBF) and heart rate (HR) but decreased the mean aortic pressure (mAoP). SF alone did not produce any significant hemodynamic changes. But when the two were administered in combination, SF antagonized dose dependently the hemodynamic action of TMPP. CONCLUSION: The results do not support the clinical combined application of Ligusticum Wallichi and Angelica root.
Keywords:tetramethylpyrazine  ferulicacid  hemodynamics  combined drug
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