| 安体欣对130 dB次声作用后大鼠脑、肺组织SOD活性及MDA含量的影响 |
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| 引用本文： | 赵志刚,胡德华,张李燕,陈景藻.安体欣对130 dB次声作用后大鼠脑、肺组织SOD活性及MDA含量的影响[J].第四军医大学学报,2007,28(3):220-221. |
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| 作者姓名： | 赵志刚 胡德华 张李燕 陈景藻 |
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| 作者单位： | 1. 第四军医大学预防医学系放射医学教研室,陕西,西安,710033
2. 解放军第264医院医务处,山西,太原,030001 |
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| 基金项目： | 军队指令性项目，01L071， |
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| 摘 要： | 目的:观察安体欣对16 Hz,130 dB次声连续作用后,大鼠脑、肺组织SOD活性及MDA含量的影响. 方法: 预服不同剂量的安体欣后,用16 Hz,130 dB次声连续作用2 h/(次·d)×14次,分别于作用后0.5 h观察大鼠脑、肺组织SOD活性及MDA含量. 结果: 次声作用后,动物脑、肺组织SOD活性和MDA含量升高(P＜0.01),预服安体欣后使脑、肺组织SOD和MDA含量下降. 结论: 次声确可影响体内自由基代谢,安体欣可以减轻有害的自由基反应.
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| 关 键 词： | 次声 超氧化物歧化酶 丙二醛 安体欣 |
| 文章编号： | 1000-2790(2007)03-0220-02 |
| 修稿时间： | 2005年12月23 |
Effect of ANTIXIN on SOD activity and MDA content in lung and brain of rats exposed to 130 dB infrasound |
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| ZHAO Zhi-Gang,HU De-Hua,ZHANG Li-Yan,CHEN Jing-Zao.Effect of ANTIXIN on SOD activity and MDA content in lung and brain of rats exposed to 130 dB infrasound[J].Journal of the Fourth Military Medical University,2007,28(3):220-221. |
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| Authors: | ZHAO Zhi-Gang HU De-Hua ZHANG Li-Yan CHEN Jing-Zao |
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| Abstract: | AIM: To observe the effect of ANTIXIN on the serumSOD activity and MDA content in the tissues of lung and brain of the rats exposed to the continuous infrasound of 130 dB (16 Hz). METHODS: Taking different doses of ANTIXIN orally in advance, the rats were exposed to the continuous 130 dB (16 Hz) infrasound for 14 d (2 h/d). Half an hour after each exposure, the serum SOD activity and MDA content of the rats were observed respectively. RESULTS: The SOD activity and MDA content in tissues of lung and brain of the animals exposed to the infrasound increased (P<0.01). When the rats took ANTIXIN orally in advance, the SOD activity and MDA content in tissues of lung and brain decreased. CONCLUSION: Infrasound can surely affect the metabolism of the free radicles in organism. ANTIXIN can extenuate the harmful free radical reactions. |
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| Keywords: | infrasound superoxide dismutase malondial- dehgde ANTIXIN |
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