增生性玻璃体视网膜病变增生膜中survivin基因的表达 |
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引用本文: | 王静波,惠延年,马吉献,苏静波.增生性玻璃体视网膜病变增生膜中survivin基因的表达[J].第四军医大学学报,2003,24(13):1167-1168. |
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作者姓名: | 王静波 惠延年 马吉献 苏静波 |
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作者单位: | 第四军医大学西京医院眼科,陕西,西安,710033 |
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基金项目: | 国家自然科学基金 (39970 780 ) |
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摘 要: | 目的:探讨凋亡抑制基因survivin在增生性玻璃体视网膜病变(PVR)增生膜中的表达.方法:玻璃体手术中取出的10例PVR患的增生膜,应用免疫组织化学方法(SABC法)检测增生膜中survivin基因的表达.结果:10例增生膜中,6例表达阳性.阳性染色位于膜上大部分细胞的胞质内及细胞外基质中。结论:Survivin基因的异常表达引起细胞的凋亡抑制,在PVR的发生中起一定作用。
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关 键 词: | 玻璃体视网膜病 增生性 细胞凋亡 survivin 基因表达 |
文章编号: | 1000-2790(2003)13-1167-02 |
修稿时间: | 2003年2月20日 |
Expression of survivin gene in periretinal membranes of proliferative vitreoretinopathy |
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Abstract: | AIM: To study the expression of survivin, an inhibitor gene of apoptosis, in periretinal membrane of proliferative vitreoretinopathy (PVR). METHODS: 10 periretinal membranes obtained from 10 cases of PVR with retinal detachment undergoing vitretomy were used to examine the expression of survivin gene by SABC method. RESULTS: Survivin gene was expressed in 6 of the 10 cases. The reactions of survivin were observed in the ctyoplasm and extracellular matrix. CONCLUSION: The abnormal expression of survivin gene inhibits apoptosis and it may participate in the progression of proliferative vitreoretinopathy. |
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Keywords: | vitreoretinopathy proliferative apoptosis survivin |
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