慢性乙型肝炎患者外周血淋巴细胞亚群及膜白细胞介素2受体表达的研究

目的：探讨乙型病毒性肝炎（乙肝）患者外周血淋巴细胞亚群及膜表面白细胞介素２受体（ｍＩＬ－２Ｒ）与乙肝发病机制的关系．方法：采用ＡＰＡＡＰ技术检测９２例慢性乙肝患者外周血淋巴细胞亚群及ｍＩＬ－２Ｒ．结果：慢性乙肝患者ＣＤ＋４细胞数明显降低（Ｐ＜０．０５），ＣＤ＋８细胞数显著上升（Ｐ＜０．０５或Ｐ＜０．０１），以致ＣＤ＋４／ＣＤ＋８比值下降；ｍＩＬ－２Ｒ显著低于正常对照组（Ｐ＜０．０５），在ＰＨＡ激活后与正常接近，但均较ＰＨＡ激活前显著增高（Ｐ＜０．０１）．２０例慢活肝恢复期ｍＩＬ－２Ｒ已趋于正常．结论：慢性乙肝患者存在着免疫调节功能异常，可能与乙型肝炎病毒的持续存在互为因果关系．

Study of peripheral blood T lymphocytes subsets and membrane interleukine 2 receptors in patients with chronic hepatitis B

Objective: To investigate the relationship between peripheral blood T lymphocytes subsets (PBTL) and membrane interleukine 2 receptors (mIL 2R) in chronic hepatitis B. Methods: Using APAAP method, we tested T cell subsets and mIL 2R in 92 patients with chronic hepatitis B. Results: It was found that the number of CD + 4 cells greatly decreased ( P <0.05) while that of CD + 8 cells markedly increased ( P < 0.05 or P <0.01) resulting in the fall of the ratio of CD + 4/CD + 8 ( P <0.05). The level of mIL 2R was significantly lower than that in the control group ( P <0.05), while approached after PHA stimulation, but both were higher than that before PHA stimulation ( P <0.01). During the recovering period of the 20 cases of chronic active hepatitis (CAH), mIL IR + cells approximately tended to the normal level. Conclusion: The results indicate that the patients suffer the abnormality of immunoregulation which may play some roles in persistent virus existence.