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| 新生大鼠脑缺氧缺血后海马CA1区HSP70表达及GM1作用 | |
| 引用本文： | 曹艳华,王玲,惠延平,曹玉红.新生大鼠脑缺氧缺血后海马CA1区HSP70表达及GM1作用[J].第四军医大学学报,2003,24(12):1097-1099. |
| 作者姓名： | 曹艳华 王玲 惠延平 曹玉红 |
| 作者单位： | 1. 第四军医大学唐都医院儿科,陕西,西安,710038 2. 第四军医大学基础部病理学教研室,陕西,西安,710033 3. 第四军医大学西京医院儿科,陕西,西安,710033 |
| 摘 要： | HI后新生大鼠海马CA1区仅能检出少量阳性HSP核蛋白(仅在核内表达的蛋白)，海马CA1区神经元呈较严重的缺血损伤性改变。而GM1组可见应激蛋白HSP70明显表达，24h达高峰。结论：GM1可使新生大鼠海马CA1区HSP70表达上调，减轻脑缺氧缺血后病理损伤，对新生大鼠缺氧缺血性脑损伤具有保护作用。 |
| 关 键 词： | G（M1）神经节苷脂 热休克蛋白质类70 脑 缺氧脑缺血 新生大鼠 |
| 文章编号： | 1000-2790(2003)12-1097-03 |
| 修稿时间： | 2002年9月13日 |
Effect of GM1 on HSP70 expression and pathologic damage in hippocampal CA1 in neonatal rat model of hypoxic-ischemia |
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| Abstract: | AIM: To study the expression of HSP70 and pathologic damage in hippocampal CA 1 after hypoxic ischemic brain damage(HIBD)in neonatal rats and the effect of monosialotetrahexosylganglioside(GM 1)on it . METHODS: Animal models of neonatal hypoxic ischemic brain damage were set up.We investigated the expression of HSP70 with immunohistochemistry and pathologic changes with HE stain ing. RESULTS: The expression of HSP70 was hardly observed in hippocampal CA 1 after HI in neonatal rats. Neurons in hippocampal CA 1 showed severe ischemic damage. The expression of HSP70 and the pathologic changes had more remarkable improvement after GM 1 administration in GM 1 group than that in HI group. CONCLUSION: GM 1 could improve the expression of HSP70 protein and reduce HIBD pathologic injury; GM 1 has the effect of brain protection against hypoxic ischemia. |
| Keywords: | G(M 1) ganglioside heat shock proteins 70 cerebral anoxia cerebral ischemia neonatal rats |
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