推拉动作对大鼠记忆功能和行为的影响

目的 探讨推拉动作后再高G值暴露对大鼠记忆功能和行为的影响。方法 24只雄性SD大鼠随机分为对照组、＋10Gz/3min组和推拉组3组，每组8只。记录＋Gz暴露后不同时间大鼠记忆功能和行为的变化。结果 推拉组大鼠正确反应率在暴露后即刻与2d时较对照组显著降低（P＜0．01），反应时在暴露后即刻、2d及4d时较对照组及＋10Gz/3min组显著延长（P＜0．01），错误数及错误时间在暴露后6h及6d时较对照组及＋10Gz/3min组显著增加（P＜0．01），潜伏期在暴露后6h,2d,4d及6d时较对照组及＋10Gz/3min组显著缩短（P＜0．01），理毛次数在暴露后6h时与对照组相比显著减少（P＜0．05），中央格内停留时间在暴露后即刻与对照组及＋10Gz/3min组相比显著延长（P＜0．01），平衡能力在暴露后即刻及2d时较对照组和＋10Gz/3min组显著降低（P＜0．01）。结论 推拉动作后再进行＋10Gz/3min暴露可导致大鼠严重的持续性记忆功能障碍和平衡失调。

Effect of push-pull maneuver on rat's memory and behavior

AIM To explore the effect of push pull maneuveron rat's memory and behavior. METHODS Twenty four male SD rats were randomly divided into three groups: the control group, the push pull and the +10 Gz/3 min groups. The changes in rat's memory and behavior were measured after +Gz exposure. RESULTS As compared with the control, rate of right reflex decreased significantly immediately and 2 days after push pull effect ( P <0.01); the number of make up decreased significantly 6 hours after the push pull effect ( P <0.05). As compared with the control and +10 Gz/3 min, time of reaction lengthened significantly at immediately, 2 days and 4 days after the push pull effect ( P < 0.01); the number of error and time of errors increased significantly 6 hours and 6 days after the push pull effect ( P < 0.01); latent time decreased significantly, 6 hours, 2 days, 4 days and 6 days after the push pull effect ( P <0.01); time stay in center grille lengthened significantly immediately after push pull effect ( P <0.01); balance function decreased significantly immediately and 2 days after the push pull effect ( P <0.01). CONCLUSION It is suggested that the exposure to +10 Gz for three minutes after 1 Gz exposure may induce a sustained disturbance in rat's memory and balance functions.