| CYP1A1与GSTM1基因的多态性与西安地区食管癌的关系 |
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| 引用本文： | 王安辉,孙长生,李良寿,黄久仪,程庆书,顾丙权,朱以芳,闫明晓.CYP1A1与GSTM1基因的多态性与西安地区食管癌的关系[J].第四军医大学学报,2002,23(1):53-55. |
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| 作者姓名： | 王安辉 孙长生 李良寿 黄久仪 程庆书 顾丙权 朱以芳 闫明晓 |
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| 作者单位： | 1. 第四军医大学预防医学系流行病学教研室,陕西,西安,710033
2. 第四军医大学唐都医院胸外科,陕西,西安,710038 |
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| 基金项目： | 国家自然科学基金资助项目 (3 9670 651) |
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| 摘 要： | 目的 探讨细胞色素p450代谢酶1A1（CYP1A1）、谷胱苷肽转硫酶μ（GSTM1）基因多态性与西安地区食管癌的关系。方法 应用分子流行病学研究方法，调查分析了西安地区108例食管癌病例和101例对照CYP1A1与GSTM1基因多态性。结果 CYP1A1 Ile/Ile,Ile/Val,Val/Val基因型在病例和对照中分别为22.6%，43.4%，34.0%和30.7%，47.5%，21.8%；其中Val/Val基因型在两间差异显（P＝0.049）；GSTM1存在型、缺失型在病例，对照中分别为40.7%，59.3%和56.4%，43.6%差异显（P＝0.023）。结论 CYP1A1 Val/Val基因基因型（突变纯合子）与GSTM1的缺失与西安地区食管癌的遗传易感性有关。
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| 关 键 词： | 食管癌 流行病学 生物学标记 CYP1A1 |
| 文章编号： | 1000-2790(2002)01-0053-03 |
| 修稿时间： | 2001年9月8日 |
CYP1A1 and GSTM1 gene polymorphism of esophageal cancer in Xi'an |
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| WANG An Hui ,SUN Chang Sheng ,LI Liang Shou ,HUANG Jiu Yi ,CHENG Qing Shu ,GU Bing Quan ,ZHU Yi Fang ,YAN Min Xiao.CYP1A1 and GSTM1 gene polymorphism of esophageal cancer in Xi''''an[J].Journal of the Fourth Military Medical University,2002,23(1):53-55. |
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| Authors: | WANG An Hui SUN Chang Sheng LI Liang Shou HUANG Jiu Yi CHENG Qing Shu GU Bing Quan ZHU Yi Fang YAN Min Xiao |
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| Institution: | WANG An Hui 1,SUN Chang Sheng 1,LI Liang Shou 1,HUANG Jiu Yi 1,CHENG Qing Shu 2,GU Bing Quan 2,ZHU Yi Fang 2,YAN Min Xiao 1 1Department of Epidemiology,Faculty of Preventive Medicine,Fourth Military Medical University,Xi' |
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| Abstract: | AIM To test the association of polymorphism of CYP1A1 and GSTM1 genotype and esophageal cancer (EC) in Xi'an. METHODS A molecular epidemiological study was carried out. Polymorphism of CYP1A1 and GSTM1 in108 EC and 101 control samples were detected by PCR method. RESULTS The proportion of CYP1A1 Ile/Ile, Ile/Val and Val/Val gene in cases and controls were 22.6%, 43.4% , 34.0% and 30.7%, 47.5%, 21.8% respectively, and Val/Val genotype was significantly different ( P = 0.049 ); GSTM1 deletion in cases and controls were 59.3% and 43.6% ( P =0.023). Moreover CYP1A1 Val/Val genotype and GSTM1 deletion were more expressed in Xi'an EC. CONCLUSION The CYP1A1 Val/Val genotype and GSTM1 deletion are related with the genetic susceptibility of EC in Xi'an. |
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| Keywords: | esophageal neoplasms epidemiology biological markers |
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