乙肝疫苗接种无、弱应答与遗传因素关系

从现场流行病学和实验研究两方面探讨乙肝疫苗接种无、弱应答是否与遗传因素有关。方法健康小学生６３４名接种３针血源性乙肝疫苗，共筛选出２９我、弱应答，同时选择３０名强应答作为对照，对无、弱应答和强应答一级亲属中符疫苗接种条件的对象接种３针乙肝疫苗，观察免疫反应。另外，从无、弱应答和强应答中选择部分对象检测了人类白细胞抗原（ＨＬＡ）－Ａ，Ｂ，Ｃ，ＤＲ，ＤＱ座位等位基因。结果小学生无、弱应答率为

Relationship between genetic factor and non-and hypo-response to hepatitis B vaccine

AIM To evaluate if genetic factor is related to the development of non and hypo response to hepatitis B vaccine by field epidemiology and experimental study. METHODS 634 healthy primary school students were vaccinated with 3 doses of plasma derived hepatitis B vaccine. 29 non and hypo responders were screened and 30 hyper responders were selected as controls. The first degree relatives (siblings and parents) of non and hypo responders and hyper responders who met the requirements of inoculation were immunized with 3 doses of hepatitis B vaccine and followed up. Furthermore, some non or hypo responders and hyper responders were tested alleles of HLA A, B, C, DR, DQ locus. RESULTS The non and hypo response rate in the immunized primary school students was 4.6% (29/634). After the immunization of hepatitis B vaccine, the frequency of non and hypo response in the first degree relatives of non and hypo responders was 25.0% and only 10.0% in hyper responders. The phenotype frequency of HLA DR7 and B54 in non and hypo responders was 52.2% and 21.7%, higher than 9.1% and 0 in hyper responders. The frequency of extended haplotype B54 DR7 was 17.0% in non and hypo responders, but 0 in hyper responders. CONCLUSION Genetic factor is associated with non and hypo response to hepatitis B vaccine.