宫颈癌组织CD44v6表达的意义

目的　探讨 CD4 4 v6在宫颈癌前病变及宫颈癌中的表达及其临床意义 .方法　应用 S- P免疫组化法观察宫颈癌6 0例、正常宫颈上皮组织 10例和宫颈上皮内瘤样病变 (CIN)12例中 CD4 4 v6的表达 .结果　正常宫颈上皮组织中CD4 4 V6阳性率为 2 0 % ,CIN中 CD4 4 v6阳性率为 4 2 % ,而宫颈癌组织中 CD4 4 v6阳性率为 6 8% .在宫颈癌中 ,随病理分级的升高 ,CD4 4 v6表达增加 ,其 , 及 级 CD4 4 v6阳性率分别为 4 3% ,6 9%和 85 % (P<0 .0 5 ) .CD4 4 v6表达在有淋巴结转移组中 (91% )明显高于无淋巴结转移组 (5 2 % ,P<0 .0 5 ) .临床分期晚 CD4 4 v6表达高 , , 期和 , 期CD4 4 v6阳性率分别为 6 3%和 80 % ,但无统计学意义 (P>0 .0 5 ) .结论　随着宫颈癌的发生、发展 ,CD4 4 v6表达率逐渐增加 ,CD4 4 v6可作为判断宫颈癌恶性程度、转移及预后的重要指标

CD44v6 expression and its significance in cervical cancer tissue

AIM To Study the clinical significance of CD44v6 expression in cervical cancer. METHODS Specimens of 60 cervical cancer, 10 normal cervical epithelia and 12 cervical intraepithelial neoplasia (CIN) were examined for CD44v6 expression by immunohistochemical staining. RESULTS Positive staining was seen in 20% of normal cervical epithe lia, 42% of CIN, 68% of cervical cancer. In cervical cancer, the frequency of abnormal CD44v6 expression was correlatedto pathologic grade and lymph node metastasis ( P <0.05). The higher the pathologic grade of tumor, the more the expression of CD44v6. Positive CD44v6 expression was significantly more frequent in the advanced stage of cervical cancer with lymph node metastasis. CONCLUSION Decreased expression of CD44v6 is a useful parameter of cervical malignancy.