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| 8 Hz/90 dB次声暴露后心肌细胞凋亡及相关机制研究 | |
| 引用本文： | 么晓轶,裴兆辉,朱妙章,陈景藻.8 Hz/90 dB次声暴露后心肌细胞凋亡及相关机制研究[J].第四军医大学学报,2006,27(6):490-492. |
| 作者姓名： | 么晓轶 裴兆辉 朱妙章 陈景藻 |
| 作者单位： | 1. 哈尔滨医科大学第一临床医院老年病科,黑龙江,哈尔滨,150086 2. 第四军医大学基础部生理教研室 3. 第四军医大学西京医院次声实验室,陕西,西安,710033 |
| 基金项目： | 国家自然科学基金资助（30400091） |
| 摘 要： | 目的：观察不同时间90dB次声诱导的大鼠心肌细胞凋亡，并探讨其相关机制．方法：用8Hz／90dB的次声分别作用大鼠1，7，14，21和28d，每日2h，观察大鼠心肌细胞凋亡率的变化，测定大鼠7心肌细胞钙离子浓度的变化．结果：大鼠心肌细胞凋亡率随时间逐渐增大（P〈0．01），大鼠心肌细胞内钙离子浓度随时问逐渐增多（P〈0．01）．结论：90dB次声可引起大鼠心肌凋亡，与次声暴露时间有关． |
| 关 键 词： | 次声 大鼠 心肌 细胞凋亡 钙 |
| 文章编号： | 1000-2790(2006)06-0490-03 |
| 收稿时间： | 2005-08-07 |
| 修稿时间： | 2005-09-12 |
Effect of 8 Hz/90 dB infrasound on rat cardiac cell apoptosis and its underlying mechanism |
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| YAO Xiao-Yi,PEI Zhao-Hui,ZHU Miao-Zhang,CHEN Jing-Zao.Effect of 8 Hz/90 dB infrasound on rat cardiac cell apoptosis and its underlying mechanism[J].Journal of the Fourth Military Medical University,2006,27(6):490-492. | |
| Authors: | YAO Xiao-Yi PEI Zhao-Hui ZHU Miao-Zhang CHEN Jing-Zao |
| Abstract: | AIM: To observe the changes of cardiac cell apoptosis in rats exposed to infrasound with 8 Hz of 90 dB for different time periods and to study its underlying mechanism. METHODS: The rats were exposed to infrasound with 8 Hz/90 dB 2 h daily for 1, 7, 14, 21 and 28 d and then the cardiac cell apoptosis and the Ca 2+ ] change in cardiac cells were measured. RESULTS: Cardiac cell apoptosis rate increased as time went on (P<0.01) and Ca 2+ ] in cardiac cells significantly increased as time went by(P<0.01). CONCLUSION: The 90 dB infrasound can induce the cardiac cell apoptosis. These changes are positively associated with the infrasound exposure time. |
| Keywords: | infrasound rats myocardium apoptosis calcium |
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