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| 复方丹参滴丸人含药血清中丹参相关代谢产物的分析 | |
| 引用本文： | 郑晓晖,王世祥,赵新锋,赵欣,刘青,郑建斌.复方丹参滴丸人含药血清中丹参相关代谢产物的分析[J].第四军医大学学报,2007,28(5):435-437. |
| 作者姓名： | 郑晓晖 王世祥 赵新锋 赵欣 刘青 郑建斌 |
| 作者单位： | 1. 西北大学分析科学研究所,陕西,西安,710069;西安交通大学中草药现代化研究及工程中心,陕西,西安,710061 2. 西北大学分析科学研究所,陕西,西安,710069 3. 西安交通大学中草药现代化研究及工程中心,陕西,西安,710061 |
| 基金项目： | 陕西省中医管理局资助项目，陕西省重大项目 |
| 摘 要： | 目的:研究复方丹参滴丸人含药血清中丹参相关代谢产物,推测其代谢机制. 方法:柱切换-高效液相色谱法富集和分离血清样品中的代谢物,电喷雾离子阱质谱法进行检测,多级质谱技术确定代谢物的碎片结构,推测其结构. 结果:在人含药血清中检测到了5个新的代谢产物,分析了各代谢物的体内形成机制. 结论:本研究可为复方丹参滴丸体内物质基础的研究打下基础. |
| 关 键 词： | 复方丹参滴丸 含药血清 色谱法 高压液相 代谢 |
| 文章编号： | 1000-2790(2007)05-0435-03 |
| 修稿时间： | 2006-12-12 |
Analysis on Danshen-related metabolites induced by Compound Danshen Dripping Pills in human serum |
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| ZHENG Xiao-Hui,WANG Shi-Xiang,ZHAO Xin-Feng,ZHAO Xin,LIU Qing,ZHENG Jian-Bin.Analysis on Danshen-related metabolites induced by Compound Danshen Dripping Pills in human serum[J].Journal of the Fourth Military Medical University,2007,28(5):435-437. | |
| Authors: | ZHENG Xiao-Hui WANG Shi-Xiang ZHAO Xin-Feng ZHAO Xin LIU Qing ZHENG Jian-Bin |
| Abstract: | AIM: To detect Danshen-related metabolites induced by Compound Danshen Dripping Pills in human serum and elucidate the possible metabolic pathway of those metabolites. METHODS: Column switching-high performance liquid chromatography was used to concentrate and separate the metabolites, which were detected by electrospray ionization trap mass spectro-metry. The structure of the metabolites was analyzed by multi-stage mass spectrometry. RESULTS: Five new metabolites were found and their possible metabolic pathways were elucidated. CONCLUSION: This work has contributed to studying the intracorporal substantial foundation of Compound Danshen Dripping Pills. |
| Keywords: | Compound Danshen Dripping Pills ionization chromatography high pressure liquid metabolism |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |