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复合材料修复骨缺损血管化及结构特征变化
引用本文:周勇,范清宇,蒋维中,文艳华,周慧.复合材料修复骨缺损血管化及结构特征变化[J].第四军医大学学报,2000,21(8):998-1001.
作者姓名:周勇  范清宇  蒋维中  文艳华  周慧
作者单位:1. 第四军医大学唐都医院全军骨科中心,陕西,西安,710038
2. 新疆乌鲁木齐86673部队
摘    要:目的:观察骨水泥、脱钙骨基质骨粒、骨形态发生蛋白生物性复合材料修复兔尺骨骨缺损血管化及结构特征变化。方法复合材料植入实验性骨缺损部位不同时间组行印度墨汁动脉血管灌注及材料自然断面扫描电镜观察,分析其血管生成及结构特征变化。结果材料植入第2周即见材料外周及两端血管形成密集,开始向材料中长入;第4,8,12周新生血管明显逐渐增多,且深入至材料中央,第4周原自然裂隙部分即骨水泥与骨粒间多点面状结合后其间

关 键 词:脱钙骨基质骨粒  骨水泥  BMP  修复  骨缺损血管化

Circulative and structural changes in the compound material of decalcified bone matrix particles combined with rhBMP-2 impregnated with bone cement for the repairment of bone defect
ZHOU-Yong,FAN Qing-Yu,JIANG Wei-Zhong,WEN Yan-Hua,ZHOU-Hui.Circulative and structural changes in the compound material of decalcified bone matrix particles combined with rhBMP-2 impregnated with bone cement for the repairment of bone defect[J].Journal of the Fourth Military Medical University,2000,21(8):998-1001.
Authors:ZHOU-Yong  FAN Qing-Yu  JIANG Wei-Zhong  WEN Yan-Hua  ZHOU-Hui
Abstract:AIM To investigate the circulative and structural changes in the compound material of decalcified bone matrix (DBM) particles which was combined with rhBMP 2 impregnated with bone cement for repairment of experimental bone defect. METHODS Intravascular injection of India ink and scan electron microscopy (SEM) were used to assess the changes.RESULTS By intravascular injection of India ink, a number of regenerative blood vessels gathered around the implanted material and began to grow into the material at the 2nd week after the operation. The number of blood vessels that grew into the implanted material increased gradually at the 4th,8th and12th weeks after the operation. The SEM observation of the structural changes indicated that, at the 4th week, some regenerative collagen was formed in the implanted material and the ossification developed from the collagen was seen in some places. A large amount of new bone was found to have covered the DBM particles and the bone cement along the irregular gaps from the 8th to 12th weeks and the irregular gaps were filled up by the regenerative tissues. CONCLUSIONS The compound material of DBM particles combined with rhBMP 2 impregnated with bone cement is significantly favorable for the bone conduction and induction. It can be used effectively for the repairment of segmental bone defects.
Keywords:decalcified bone matrix  bone cement    recombinant human BMP  2  bone defect
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