牛骨形态发生蛋白复合微孔钛与骨界面疲劳损伤机理研究

观察微孔涂层假体与骨界面疲劳行为及影响因素，方法：将牛骨形态发生蛋白复合微孔涂层的钛合金假体植入犬股骨近侧，４，８周后取标本，干燥，在配置产皮劳台的扫描电镜下动态观察在周胶变载吓界面损伤机理。结论：微孔内骨组织改建状态对于界面疲劳损伤过程具有重要的影响。

Study on mechanism of fatigue damage of interface between bone and porous coated Ti 6AI 4V implants incorporated with BMP

Objective: To look into the fatigue behavior of interface between bone and porous coated titanium alloy implants (PCI). Methods: 220 mm 2 PCI incorporated with BMP (10 mg) were inserted into the proximal femurs of adult canines. The proximal femurs and the implants were harvested en block 4 and 8 weeks post implantation and fixed in 10% formlin. Thereafter, the interface between bone and porous coated layer were exposed and dried soon after. Scanning electron microscope with a fit in computer controlled fatigue machine was employed to observe the mechanism of micro injury of the interface under fatigue load. Results: 1. BMP seemed to facilitate the ingrowth and remodelling of osseous tissue in the pores. 2. With the periodical fatigue load ranged from 0.91 to 1.86 MPa, the microscopical crack appeared at the proximal part of the interface and extended gradually to the distal part along the interface, in company with smashing, sinking and changing of bone collagen and forming of ditch lines in the porous structure. The ditch lines, which were parallel to the interface, deepened gradually and finally led to the formation of major crack. Conclusions: The remodelling state in the pores may influence the pattern of fatigue injury of the interface between bone and porous coated layer.