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Gene Expression Profile of Human Skeletal Muscle and Adipose Tissue of Chinese Han Patients with Type 2 Diabetes Mellitus |
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| Authors: | YAN-LI YANG RUO-LAN XIANG# CHANG YANG XIAO-JUN LIU WEN-JUN SHEN JIN ZUO YONG-SHENG CHANG FU-DE FANG |
| Institution: | YAN-LI YANG*,2,RUO-LAN XIANG#,CHANG YANG,XIAO-JUN LIU,WEN-JUN SHEN,JIN ZUO,YONG-SHENG CHANG,3,AND FU-DE FANG,3 *Department of Internal Medicine,Peking Union Medical College Hospital,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing 100730,China,#Department of Physiology and Pathophysiology,Peking University Health Science Center,Beijing 100083,National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Peking Union Medical College... |
| Abstract: | Objective To study the differential patterns of gene expression in skeletal muscle and adipose tissue between type 2 diabetes mellitus (T2DM) patients and healthy subjects using DNA microarray analysis. Methods T2DM patiens were divided into female group, young male group and old male group. DNA microarray analysis and quantitative real-time PCR were carried out to analyze the relation between gene expressions and T2DM. Results The mRNA expression of 298, 578, and 350 genes was changed in the skeletal muscl... |
| Keywords: | Type 2 diabetes mellitus (T2DM) Microarray technology Skeletal muscle Adipose tissue |
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