Combined Toxicity of an Environmental Remediation Residue,Magnetite Fe3O4 Nanoparticles/Cr(VI) Adduct |
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| Authors: | LI Zhuan LIU Miao CHEN Li Ke LI Guang Zhu |
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| Institution: | 1. College of Environment and Resource, Jilin University, Changchun 130012, Jilin, China;Environmental Monitoring Center of Jilin Province, Changchun 130011, Jilin, China;2. College of Environment and Resource, Jilin University, Changchun 130012, Jilin, China;3. College of Water Conservancy and Environmental Engineering, Changchun Institute of Technology, Changchun 130011, Jilin, China |
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| Abstract: | Objective This paper aims to elucidate the combined toxicity of magnetite nanoparticles/Chromium MNPs/Cr(VI)] adducts. Methods The HEK293 cell was exposed to either Cr(VI) or MNPs, or their adducts MNPs/Cr(VI). The cytotoxicity was evaluated by assessing the cell viability, apoptosis, oxidative stress induction, and cellular uptake. Results The toxicity of formed adducts is significantly reduced when compared to Cr(VI) anions. We found that the cellular uptake of MNPs/Cr(VI) adduct was rare, only few particles were endocytosed from the extracellular fluid and not accumulated in the cell nucleus. On the other hand, the Cr(VI) anions entered cells, generated oxidative stress, induced cell apoptosis, and caused cytotoxicity. Conclusion The results showed minor effects of the nanoadducts on the tested cells and supported that magnetite nanoparticles could be implemented in the wastewater treatment process in which advantageous properties outweigh the risks. |
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| Keywords: | Magnetite Fe3O4 Chromium Adduct Toxicity |
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