脊神经节射频联合臭氧治疗PHN疗效观察

目的 比较脊神经节脉冲射频联合臭氧与单纯脊神经节脉冲射频治疗带状疱疹后神经痛（postherpetic neuralgia，PHN）的疗效。方法 将符合纳入标准的胸背部PHN患者68例，随机分为两组：对照组（n=34）为脊神经节脉冲射频治疗组，试验组（n=34）为脊神经节脉冲射频联合臭氧治疗组。观察并比较两组治疗前、治疗后1、3、7天、1、3及6个月的视觉模拟评分法（visual analogue scale，VAS），并评价临床治疗效果。结果 两组治疗后VAS较治疗前均明显下降（P=0.000）。与对照组相比，试验组在治疗后1、3天VAS差异无统计学意义（P > 0.05），但治疗后7天、1、3及6个月VAS评分明显下降（P < 0.05），试验组显效率明显高于对照组，差异有统计学意义（P < 0.05）。两组患者均获得比较满意的疗效，对照组、试验组有效率分别为85.29%和91.18%，差异无统计学意义（P > 0.05），而试验组显效率（70.59%）明显高于对照组（38.24%），差异有统计学意义（P < 0.05）。结论 治疗带状疱疹后神经痛，脊神经节脉冲射频治疗及脊神经节脉冲射频联合臭氧治疗均有效，但中长期内脊神经节脉冲射频联合臭氧治疗效果更优于单纯脊神经节脉冲射频治疗，因此是一种安全有效的方法。

Clinical Observation of Treating PHN by Dorsal Root Ganglia Radio Frequency Combined Ozone

Objective To compare the curative effect of treating postherpetic neuralgia (PHN) by dorsal root ganglia pulsed radiofrequency combined ozone and simple dorsal root ganglia pulsed radiofrequency. Methods 68 cases of chest and back PHN patients in accordance with incorporation standard were randomly divided into two groups:control group (n=34) received dorsal root ganglia pulsed radiofrequency while experimental group (n=34) received dorsal root ganglia pulsed radiofrequency combined ozone. The visual analogue scale (VAS) of two groups before treatment, and 1, 3, 7 days, 1, 3 and 6 months after treatment was observed and compared; the clinical treatment effect was evaluated. Results VAS of two groups after treatment all declined obviously compared with that before treatment (P=0.000). Compared with control group, the VAS of experimental group 1 and 3 days after treatment was not significantly different (P > 0.05). However, the VAS 7 days, 1 and 3 months after treatment declined obviously (P < 0.05). The obvious effect rate of experimental group was higher than control group, so the difference was statistically different (P < 0.05). Patients in both of the groups obtained satisfying curative effect, among which the effective rates of control group and experimental group were 85.29% and 91.18% separately. The difference was not statistically different (P < 0.05). But the obvious effect rate of experimental group (70.59%) was higher than control group (38.24%), and the difference was statistically different (P < 0.05). Conclusion Both dorsal root ganglia pulsed radiofrequency combined ozone and simple dorsal root ganglia pulsed radiofrequency generate effect in treating postherpetic neuralgia. But the curative effect of dorsal root ganglia pulsed radiofrequency combined ozone is superior to simple dorsal root ganglia pulsed radiofrequency within medium and long term; therefore, it is a safe and effective treatment.