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帕金森病患者异动症临床特征及与GRIN2B基因多态性的关联性分析
引用本文:付利惠,江名芳.帕金森病患者异动症临床特征及与GRIN2B基因多态性的关联性分析[J].医学研究杂志,2016,45(12):43-46.
作者姓名:付利惠  江名芳
作者单位:010050 呼和浩特, 内蒙古医科大学附属医院神经内科;010050 呼和浩特, 内蒙古医科大学附属医院神经内科
基金项目:内蒙古自治区自然科学基金资助项目(2014MS0874)
摘    要:目的 探讨帕金森病患者异动症临床特征及与GRIN2B基因多态性的关联性。方法 自2012年1月~2015年12月,前瞻性收集帕金森患者178例,根据患者是否合并异动症,将患者分为异动症组和对照组,主要观察指标为GRIN2B基因的多态性,次要观察指标为两组患者的主要临床特征。结果 与对照组相比,异动症组患者发病年龄显著降低(46.34±12.32岁vs 54.45±11.35岁,P=0.000);病程显著延长(8.94±3.21年vs 7.34±2.48年,P=0.000);服药时间显著延长(69.435±19.43月vs 59.65±11.46月,P=0.000);左旋多巴剂量显著增高(577.34±248.54mg/d vs 475.87±290.43mg/d,P=0.000);H-Y分期评分显著增加(3.43±1.19 vs 2.14±0.89,P=0.015)。两组患者临床分型和性别等差异无统计学意义(P=0.596)。GRIN2B基因遗传多态性位点共出现rs34315573、rs7301328、rs1805522、rs1806201、rs1806191和rs1805246共6个多态位点。与对照组相比,异动症组患者rs34315573基因型和rs1806191基因型分布差异有统计学意义(P<0.05)。两组患者rs7301328基因型、rs1805522基因型、rs1806201基因型和rs1805246基因型分布差异无统计学意义(P>0.05)。结论 帕金森病患者异动症发病具有年轻化、病程长、服药时间长、H-Y评分增加等特点,并与GRIN2B基因多态性相关。

关 键 词:GRIN2B  基因多态性  帕金森病  异动症  临床特征
收稿时间:2016/5/7 0:00:00
修稿时间:2016/5/21 0:00:00

Clinical Features of Dyskinesia and Its Association with GRIN2B Gene Polymorphisms in Parkinson's Disease
Fu Lihui and Jiang Mingfang.Clinical Features of Dyskinesia and Its Association with GRIN2B Gene Polymorphisms in Parkinson's Disease[J].Journal of Medical Research,2016,45(12):43-46.
Authors:Fu Lihui and Jiang Mingfang
Institution:Department of Internal Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia 010050, China;Department of Internal Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia 010050, China
Abstract:Objective To investigate the clinical features of dyskinesia and its association with GRIN2B gene polymorphisms in Parkinson''s disease.Methods From Jan 2012 to Dec 2015, 178 patients with Parkinson''s disease were enrolled in this prospectively study. Patients were signed into dyskinesia group if they developed dyskinesia, while the others were assigned into the control group. The primary outcomes were GRIN2B gene polymorphisms and the secondly primary outcomes were clinical features.Results When compared with patients in the control group, patients in the dyskinesia group got a significantly lower age of onset Parkinson''s disease (46.34±12.32 years vs 54.45±11.35 years,P=0.000); a significantly longer course of disease (8.94±3.21 years vs 7.34±2.48 years, P=0.000); a significantly longer drug administration time (69.435±19.43 months vs 59.65±11.46 months, P=0.000); a significantly higher dosage of L dopamine per day (577.34±248.54mg/d vs 475.87±290.43mg/d, P=0.000); and a significantly higher classification score of H-Y (3.43±1.19 vs 2.14±0.89, P=0.015). There was no difference between two groups in clinical type of Parkinson''s disease and gender (P>0.05). Six GRIN2B gene polymorphisms included rs34315573, rs7301328, rs1805522, rs1806201, rs1806191 and rs1805246 were found in these patients. Significantly differences were found between the two groups in rs34315573 and rsl806191 gene types (P<0.05), while there were no differences in rs7301328, rs1805522, rs1806201 and rs1805246 gene types (P>0.05).Conclusion Parkinson patients with dyskinesia has the characteristics of younger age, longer disease duration, longer medication time and higher H-Y score, and it got an apparently association with GRIN2B gene polymorphisms.
Keywords:GRIN2B  Gene polymorphisms  Parkinson''s disease  Dyskinesia  Clinical features
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